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    KCNQ KCNQ potassium channel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36071, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KCNQprovided by FlyBase
    Official Full Name
    KCNQ potassium channelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033494
    Locus tag
    Dmel_CG33135
    See related
    AllianceGenome:FB:FBgn0033494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12215; CG12915; CG33135; dKCNQ; DKCNQ; Dmel\CG33135; kcnq1; KCNQ1; KQT; KQT 1
    Summary
    Enables voltage-gated monoatomic cation channel activity. Involved in several processes, including cardiac muscle contraction; potassium ion transport; and regulation of heart rate. Located in membrane. Is expressed in several structures, including adult brain cell body rind; adult head; egg chamber; female germline cell; and lamina. Used to study heart conduction disease and long QT syndrome. Human ortholog(s) of this gene implicated in auditory system disease (multiple); autistic disorder; autosomal dominant intellectual developmental disorder 46; and electroclinical syndrome (multiple). Orthologous to several human genes including KCNQ4 (potassium voltage-gated channel subfamily Q member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See KCNQ in Genome Data Viewer
    Location:
    46F3-46F5; 2-62 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10145897..10192394, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6033402..6079899, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43467 Neighboring gene gemini Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 46a Neighboring gene antisense RNA:CR45133 Neighboring gene mulet Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46322 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hormone receptor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KCNQ channels regulate age-related memory impairment. Cavaliere S, et al. PLoS One, 2013. PMID 23638087, Free PMC Article
    2. Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels. Cavaliere S, et al. PLoS One, 2011. PMID 21915266, Free PMC Article
    3. Mulet (mlt) encodes a tubulin-binding cofactor E-like homolog required for spermatid individualization in Drosophila melanogaster. Fabrizio JJ, et al. Fly (Austin), 2012 Oct-Dec. PMID 22885996, Free PMC Article
    4. A Drosophila KCNQ channel essential for early embryonic development. Wen H, et al. J Neurosci, 2005 Nov 2. PMID 16267222, Free PMC Article
    5. Drosophila ortholog of succinyl-CoA synthetase {beta} subunit: a novel modulator of Drosophila KCNQ channels. Gao L, et al. J Neurophysiol, 2008 May. PMID 18385479

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c10186043-10176935 mobile_element_type = transposon:roo{}796

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables voltage-gated monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    KCNQ potassium channel
    Names
    CG33135-PC
    CG33135-PD
    CG33135-PE
    CG33135-PF
    CG33135-PG
    CG33135-PH
    CG33135-PI
    CG33135-PJ
    CG33135-PK
    KCNQ-PC
    KCNQ-PD
    KCNQ-PE
    KCNQ-PF
    KCNQ-PG
    KCNQ-PH
    KCNQ-PI
    KCNQ-PJ
    KCNQ-PK
    KCNQ-type K[+] channel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10145897..10192394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144160.2 → NP_001137632.1  KCNQ potassium channel, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZR3, H1UUH4
      Conserved Domains (3) summary
      pfam00520
      Location:66 → 271
      Ion_trans; Ion transport protein
      pfam03520
      Location:400 → 500
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:187 → 261
      Ion_trans_2; Ion channel

    2. NM_001273919.1 → NP_001260848.1  KCNQ potassium channel, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF62, H1UUH4
      Conserved Domains (3) summary
      pfam00520
      Location:97 → 302
      Ion_trans; Ion transport protein
      pfam03520
      Location:431 → 531
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:218 → 292
      Ion_trans_2; Ion channel

    3. NM_001273923.1 → NP_001260852.1  KCNQ potassium channel, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260852.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFJ4, H1UUH4
      Conserved Domains (3) summary
      pfam00520
      Location:100 → 305
      Ion_trans; Ion transport protein
      pfam03520
      Location:434 → 534
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:221 → 295
      Ion_trans_2; Ion channel

    4. NM_176119.5 → NP_788299.3  KCNQ potassium channel, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788299.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z855, H1UUH4, Q5PXF9
      Conserved Domains (3) summary
      pfam00520
      Location:100 → 305
      Ion_trans; Ion transport protein
      pfam03520
      Location:434 → 534
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:221 → 295
      Ion_trans_2; Ion channel

    5. NM_001273922.1 → NP_001260851.1  KCNQ potassium channel, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260851.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEP9, H1UUH4
      Conserved Domains (3) summary
      pfam00520
      Location:100 → 305
      Ion_trans; Ion transport protein
      pfam03520
      Location:453 → 553
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:221 → 295
      Ion_trans_2; Ion channel

    6. NM_001273921.1 → NP_001260850.1  KCNQ potassium channel, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260850.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEH2, H1UUH4
      Conserved Domains (3) summary
      pfam00520
      Location:100 → 305
      Ion_trans; Ion transport protein
      pfam03520
      Location:465 → 565
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:221 → 295
      Ion_trans_2; Ion channel

    7. NM_176120.5 → NP_788300.3  KCNQ potassium channel, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788300.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z856, H1UUH4
      Conserved Domains (3) summary
      pfam00520
      Location:100 → 305
      Ion_trans; Ion transport protein
      pfam03520
      Location:619 → 719
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:221 → 295
      Ion_trans_2; Ion channel

    8. NM_001273920.1 → NP_001260849.1  KCNQ potassium channel, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260849.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEI9, H1UUH4
      Conserved Domains (3) summary
      pfam00520
      Location:100 → 305
      Ion_trans; Ion transport protein
      pfam03520
      Location:449 → 549
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:221 → 295
      Ion_trans_2; Ion channel

    9. NM_001144159.2 → NP_001137631.1  KCNQ potassium channel, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137631.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZR4, Q8IT87
      Conserved Domains (3) summary
      pfam00520
      Location:100 → 305
      Ion_trans; Ion transport protein
      pfam03520
      Location:434 → 534
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:221 → 295
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEH2 A0A0B4KEH2
    A0A0B4KEI9 A0A0B4KEI9
    A0A0B4KEP9 A0A0B4KEP9
    A0A0B4KF62 A0A0B4KF62
    A0A0B4KFJ4 A0A0B4KFJ4
    A1Z856 A1Z856
    B7YZR3 B7YZR3
    B7YZR4 B7YZR4
    Q5PXF9 Q5PXF9
    Q8IGU8 Q8IGU8
    Q8IT87 Q8IT87

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