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    Primpol primase and DNA directed polymerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361147, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Primpolprovided by RGD
    Official Full Name
    primase and DNA directed polymeraseprovided by RGD
    Primary source
    RGD:1562119
    See related
    EnsemblRapid:ENSRNOG00000022320 AllianceGenome:RGD:1562119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc111; RGD1562119
    Summary
    Predicted to enable chromatin binding activity; nucleotidyltransferase activity; and transition metal ion binding activity. Predicted to be involved in DNA metabolic process; R-loop processing; and response to UV. Predicted to be located in mitochondrion and replication fork. Predicted to be part of DNA-directed RNA polymerase complex. Predicted to be active in mitochondrial matrix and nucleus. Human ortholog(s) of this gene implicated in myopia. Orthologous to human PRIMPOL (primase and DNA directed polymerase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 77.1), Thymus (RPKM 50.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Primpol in Genome Data Viewer
    Location:
    16q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (52413894..52450975)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (45681252..45715758)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (48863385..48900409)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L4, pseudogene 3 Neighboring gene caspase 3 Neighboring gene centromere protein U Neighboring gene acyl-CoA synthetase long-chain family member 1 Neighboring gene uncharacterized LOC108348397

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Zn-finger domain of human PrimPol is required to stabilize the initiating nucleotide during DNA priming. Martínez-Jiménez MI, et al. Nucleic Acids Res, 2018 May 4. PMID 29608762, Free PMC Article
    2. PrimPol is required for replication reinitiation after mtDNA damage. Torregrosa-Muñumer R, et al. Proc Natl Acad Sci U S A, 2017 Oct 24. PMID 29073063, Free PMC Article
    3. Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol. Martínez-Jiménez MI, et al. DNA Repair (Amst), 2015 May. PMID 25746449
    4. Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Keen BA, et al. Nucleic Acids Res, 2014 May. PMID 24682820, Free PMC Article
    5. Repriming of DNA synthesis at stalled replication forks by human PrimPol. Mourón S, et al. Nat Struct Mol Biol, 2013 Dec. PMID 24240614

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA primase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA primase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication, synthesis of primer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in R-loop processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in error-prone translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed primase/polymerase protein; primase and DNA directed polymerase
    Names
    coiled-coil domain containing 111
    primase and polymerase (DNA-directed)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432823.1 → NP_001419752.1  primase and DNA directed polymerase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D4A8C0

    2. NM_001432824.1 → NP_001419753.1  primase and DNA directed polymerase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D4A8C0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      52413894..52450975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253167.5 → XP_006253229.1  DNA-directed primase/polymerase protein

      Conserved Domains (2) summary
      pfam03121
      Location:384 → 448
      Herpes_UL52; Herpesviridae UL52/UL70 DNA primase
      cd22256
      Location:459 → 531
      PrimPol_RBD; C-terminal RPA-binding domain (RBD) of DNA-directed primase/polymerase protein and similar proteins

    2. XM_341433.9 → XP_341434.3  DNA-directed primase/polymerase protein

      Related
      ENSRNOP00000107697.1, ENSRNOT00000150556.1
      Conserved Domains (2) summary
      pfam03121
      Location:384 → 448
      Herpes_UL52; Herpesviridae UL52/UL70 DNA primase
      cd22256
      Location:459 → 531
      PrimPol_RBD; C-terminal RPA-binding domain (RBD) of DNA-directed primase/polymerase protein and similar proteins

    3. XM_039094880.2 → XP_038950808.1  DNA-directed primase/polymerase protein

      UniProtKB/TrEMBL
      D4A8C0
      Conserved Domains (2) summary
      pfam03121
      Location:384 → 448
      Herpes_UL52; Herpesviridae UL52/UL70 DNA primase
      cd22256
      Location:459 → 531
      PrimPol_RBD; C-terminal RPA-binding domain (RBD) of DNA-directed primase/polymerase protein and similar proteins

    4. XM_039094879.2 → XP_038950807.1  DNA-directed primase/polymerase protein

      UniProtKB/TrEMBL
      D4A8C0
      Conserved Domains (2) summary
      pfam03121
      Location:384 → 448
      Herpes_UL52; Herpesviridae UL52/UL70 DNA primase
      cd22256
      Location:459 → 531
      PrimPol_RBD; C-terminal RPA-binding domain (RBD) of DNA-directed primase/polymerase protein and similar proteins

    5. XM_063275860.1 → XP_063131930.1  DNA-directed primase/polymerase protein

      UniProtKB/TrEMBL
      D4A8C0

    RNA

    1. XR_005494696.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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