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    Cars2 cysteinyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cars2provided by RGD
    Official Full Name
    cysteinyl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1311612
    See related
    EnsemblRapid:ENSRNOG00000014526 AllianceGenome:RGD:1311612
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311612
    Summary
    Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 27. Orthologous to human CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 93.0), Liver (RPKM 79.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cars2 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (84649617..84689254)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (77945468..77987163)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (83288613..83325706)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097568 Neighboring gene ankyrin repeat domain 10 Neighboring gene inhibitor of growth family, member 1 Neighboring gene uncharacterized LOC134482536 Neighboring gene NAD(P)HX dehydratase Neighboring gene uncharacterized LOC102553902 Neighboring gene RAB20, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteinyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable cysteine--tRNA ligase, mitochondrial
    NP_001171155.1
    XP_006253522.3
    XP_006253523.3
    XP_006253524.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177684.1 → NP_001171155.1  probable cysteine--tRNA ligase, mitochondrial

      See identical proteins and their annotated locations for NP_001171155.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166536
      UniProtKB/TrEMBL
      A6IWP2, B2GV57, D4A5T2
      Related
      ENSRNOP00000019993.7, ENSRNOT00000019993.8
      Conserved Domains (3) summary
      cd00672
      Location:38 → 342
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      COG0215
      Location:38 → 539
      CysS; Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cl12020
      Location:391 → 427
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      84649617..84689254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253460.5 → XP_006253522.3  probable cysteine--tRNA ligase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXZ9
      Conserved Domains (1) summary
      PTZ00399
      Location:157 → 664
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    2. XM_006253461.5 → XP_006253523.3  probable cysteine--tRNA ligase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZXZ9
      Related
      ENSRNOP00000084040.2, ENSRNOT00000096918.2
      Conserved Domains (1) summary
      PTZ00399
      Location:157 → 663
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    3. XM_006253462.5 → XP_006253524.3  probable cysteine--tRNA ligase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6IWP2
      Conserved Domains (1) summary
      PTZ00399
      Location:157 → 680
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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