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    Spn47C Serpin 47C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36163, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn47Cprovided by FlyBase
    Official Full Name
    Serpin 47Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033574
    Locus tag
    Dmel_CG7722
    See related
    AllianceGenome:FB:FBgn0033574
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7722; Dmel\CG7722; spn47C
    Summary
    Involved in sexual reproduction. Predicted to be active in extracellular space. Is expressed in adult head and spermatozoon. Orthologous to human SERPINA7 (serpin family A member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn47C in Genome Data Viewer
    Location:
    47C7-47C7; 2-63 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10938425..10941738, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6825930..6829243, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene polyphemus Neighboring gene Odorant-binding protein 47a Neighboring gene long non-coding RNA:CR45228 Neighboring gene luna Neighboring gene long non-coding RNA:CR46409 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expanding the mesodermal transcriptional network by genome-wide identification of Zinc finger homeodomain 1 (Zfh1) targets. Wu WH, et al. FEBS Lett, 2019 Jul. PMID 31093969
    2. Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila. Katsukawa M, et al. Curr Biol, 2018 Jun 4. PMID 29804808
    3. A serpin that regulates immune melanization in the respiratory system of Drosophila. Tang H, et al. Dev Cell, 2008 Oct. PMID 18854145, Free PMC Article
    4. UpSET recruits HDAC complexes and restricts chromatin accessibility and acetylation at promoter regions. Rincon-Arano H, et al. Cell, 2012 Dec 7. PMID 23177352, Free PMC Article
    5. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables serine-type endopeptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin 47C
    Names
    CG7722-PA
    CG7722-PB
    CG7722-PC
    Spn47C-PA
    Spn47C-PB
    Spn47C-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10938425..10941738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299373.1 → NP_001286302.1  serpin 47C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K508
      Conserved Domains (1) summary
      cd00172
      Location:18 → 379
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_001169645.2 → NP_001163116.1  serpin 47C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K508
      Conserved Domains (1) summary
      cd00172
      Location:18 → 379
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    3. NM_136789.4 → NP_610633.1  serpin 47C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610633.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K508
      Related
      FBpp0087306
      Conserved Domains (1) summary
      cd00172
      Location:18 → 379
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K508 Q7K508

    Gene LinkOut

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