Cend1 cell cycle exit and neuronal differentiation 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cend1provided by RGD
Full Name: cell cycle exit and neuronal differentiation 1provided by RGD
Primary source: RGD:1309401
See related: EnsemblRapid:ENSRNOG00000062814 AllianceGenome:RGD:1309401
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C38; RGD1309401
Summary: Predicted to be involved in cerebellar Purkinje cell differentiation; cerebellar granular layer maturation; and radial glia guided migration of cerebellar granule cell. Predicted to act upstream of or within adult walking behavior and negative regulation of cerebellar granule cell precursor proliferation. Predicted to be located in mitochondrion and vesicle. Orthologous to human CEND1 (cell cycle exit and neuronal differentiation 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 313.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205954713..205957710, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196525153..196528152, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214407072..214410069, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C38 is a rat BM88 that is expressed in RGCs and horizontal cells in the adult rat retina. During development, C38 expression was up-regulated in parallel with neuronal maturation.
Title: C38, equivalent to BM88, is developmentally expressed in maturing retinal neurons and enhances neuronal maturation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133350 (e-PCR)
- UniSTS:216633

AI415214 (e-PCR)
- UniSTS:185743

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in cerebellar Purkinje cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebellar Purkinje cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cerebellar granular layer maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebellar granular layer maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cerebellar granule cell precursor proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in radial glia guided migration of cerebellar granule cell	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within radial glia guided migration of cerebellar granule cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell cycle exit and neuronal differentiation protein 1

Names: cell cycle exit and neuronal differentiation protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014163.1 → NP_001014185.1 cell cycle exit and neuronal differentiation protein 1

See identical proteins and their annotated locations for NP_001014185.1

Status: PROVISIONAL

Source sequence(s)

BC089963

UniProtKB/Swiss-Prot

Q5FVI4

UniProtKB/TrEMBL

B7X6I3

Related

ENSRNOP00000087482.1, ENSRNOT00000116264.2

Conserved Domains (1) summary

pfam15677
Location:1 → 149

CEND1; Cell cycle exit and neuronal differentiation protein 1