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    Tbc1d10c TBC1 domain family, member 10C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361697, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tbc1d10cprovided by RGD
    Official Full Name
    TBC1 domain family, member 10Cprovided by RGD
    Primary source
    RGD:1311490
    See related
    EnsemblRapid:ENSRNOG00000021510 AllianceGenome:RGD:1311490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311490
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to act upstream of or within negative regulation of B cell activation; negative regulation of ERK1 and ERK2 cascade; and negative regulation of calcineurin-NFAT signaling cascade. Predicted to be located in filopodium membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human TBC1D10C (TBC1 domain family member 10C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 215.3), Spleen (RPKM 188.8) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Tbc1d10c in Genome Data Viewer
    Location:
    1q43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210906621..210913649, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201476258..201484876, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219431094..219439102, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase B2 Neighboring gene carnosine synthase 1 Neighboring gene protein phosphatase 1 catalytic subunit alpha Neighboring gene RAD9 checkpoint clamp component A Neighboring gene cardiotrophin-like cytokine factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081980.1NP_001075449.1  carabin

      See identical proteins and their annotated locations for NP_001075449.1

      Status: VALIDATED

      Source sequence(s)
      BC099180, BC105899, CO564143, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HYV3, B1H212, F7ERP1
      Related
      ENSRNOP00000029272.3, ENSRNOT00000029237.8
      Conserved Domains (1) summary
      smart00164
      Location:89294
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210906621..210913649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230840.5XP_006230902.1  carabin isoform X1

      See identical proteins and their annotated locations for XP_006230902.1

      UniProtKB/TrEMBL
      A6HYV3, B1H212, F7ERP1
      Conserved Domains (1) summary
      smart00164
      Location:89294
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    2. XM_063268192.1XP_063124262.1  carabin isoform X1

      UniProtKB/TrEMBL
      A6HYV3, B1H212, F7ERP1