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    Aste1 asteroid homolog 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aste1provided by RGD
    Official Full Name
    asteroid homolog 1provided by RGD
    Primary source
    RGD:1304643
    See related
    EnsemblRapid:ENSRNOG00000013059 AllianceGenome:RGD:1304643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304643
    Summary
    Predicted to enable 3' overhang single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination and double-strand break repair via nonhomologous end joining. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to human ASTE1 (asteroid homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 63.0), Lung (RPKM 49.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aste1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (114905349..114923775)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106026570..106044694)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (113936991..113954833)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene microRNA 6330 Neighboring gene NIMA-related kinase 11 Neighboring gene spermine synthase, pseudogene 1 Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2, pseudogene 1 Neighboring gene ATPase secretory pathway Ca2+ transporting 1 Neighboring gene ribosomal protein L29, pseudogene 14 Neighboring gene ribosomal protein L29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3' overhang single-stranded DNA endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein asteroid homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040156.2 → NP_001035246.2  protein asteroid homolog 1

      Status: VALIDATED

      Source sequence(s)
      BQ193960, JAXUCZ010000008
      UniProtKB/TrEMBL
      E9PU85
      Related
      ENSRNOP00000017743.5, ENSRNOT00000017743.7
      Conserved Domains (2) summary
      pfam12813
      Location:116 → 378
      XPG_I_2; XPG domain containing
      cl14812
      Location:1 → 173
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      114905349..114923775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265809.1 → XP_063121879.1  protein asteroid homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K873, A6I2N2
      Related
      ENSRNOP00000074497.1, ENSRNOT00000065794.5

    2. XM_063265814.1 → XP_063121884.1  protein asteroid homolog 1 isoform X7

    3. XM_063265812.1 → XP_063121882.1  protein asteroid homolog 1 isoform X5

    4. XM_063265810.1 → XP_063121880.1  protein asteroid homolog 1 isoform X2

      UniProtKB/TrEMBL
      A6I2N2

    5. XM_039081782.2 → XP_038937710.1  protein asteroid homolog 1 isoform X3

      Conserved Domains (2) summary
      pfam12813
      Location:116 → 404
      XPG_I_2; XPG domain containing
      cl28905
      Location:28 → 194
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    6. XM_063265811.1 → XP_063121881.1  protein asteroid homolog 1 isoform X4

    7. XM_063265815.1 → XP_063121885.1  protein asteroid homolog 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AEP3

    8. XM_063265813.1 → XP_063121883.1  protein asteroid homolog 1 isoform X6

    9. XM_063265817.1 → XP_063121887.1  protein asteroid homolog 1 isoform X9

      UniProtKB/TrEMBL
      E9PU85

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014213.1: Suppressed sequence

      Description
      NM_001014213.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

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