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    Nacalpha Nascent polypeptide associated complex protein alpha subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nacalphaprovided by FlyBase
    Official Full Name
    Nascent polypeptide associated complex protein alpha subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086904
    Locus tag
    Dmel_CG8759
    See related
    AllianceGenome:FB:FBgn0086904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aic; alpha-NAC; alphaNAC; CG8759; Dmel\CG8759; l(2)04329; NAC; NAC-alpha; NACalpha; ubNACalpha
    Summary
    Predicted to enable ribosome binding activity and unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; larval muscle cell; presumptive embryonic/larval system; and visceral muscle primordium. Orthologous to several human genes including NACA4P (NACA family member 4, pseudogene) and NACA2 (nascent polypeptide associated complex subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nacalpha in Genome Data Viewer
    Location:
    49C2-49C3; 2-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12759693..12760999, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8647198..8648504, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tafazzin Neighboring gene Diacyl glycerol kinase epsilon Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene oxen Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45266

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clusters of temporal discordances reveal distinct embryonic patterning mechanisms in Drosophila and anopheles. Papatsenko D, et al. PLoS Biol, 2011 Jan 25. PMID 21283609, Free PMC Article
    2. 52 Genetic Loci Influencing Myocardial Mass. van der Harst P, et al. J Am Coll Cardiol, 2016 Sep 27. PMID 27659466, Free PMC Article
    3. Localization-dependent oskar protein accumulation; control after the initiation of translation. Braat AK, et al. Dev Cell, 2004 Jul. PMID 15239960
    4. The Drosophila MOS ortholog is not essential for meiosis. Ivanovska I, et al. Curr Biol, 2004 Jan 6. PMID 14711418
    5. Extended disordered regions of ribosome-associated NAC proteins paralogs belong only to the germline in Drosophila melanogaster. Kogan GL, et al. Sci Rep, 2022 Jul 1. PMID 35778515, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nascent polypeptide-associated complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nascent polypeptide associated complex protein alpha subunit
    Names
    CG8759-PA
    CG8759-PB
    CG8759-PC
    CG8759-PD
    NAC protein alpha subunit
    Nacalpha-PA
    Nacalpha-PB
    Nacalpha-PC
    Nacalpha-PD
    alpha NAC
    lethal (2) 04329
    ubiquitous NAC-alpha
    ubiquitous NACalpha

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12759693..12760999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057868.4 → NP_477216.1  nascent polypeptide associated complex protein alpha subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477216.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZF1, O16813, Q0E999, Q94518
      UniProtKB/TrEMBL
      A0A0B4LEY6
      Related
      FBpp0086971
      Conserved Domains (3) summary
      COG1308
      Location:74 → 216
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14358
      Location:179 → 215
      UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes
      pfam01849
      Location:75 → 128
      NAC; NAC domain

    2. NM_165950.2 → NP_725229.1  nascent polypeptide associated complex protein alpha subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725229.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZF1, O16813, Q0E999, Q94518
      UniProtKB/TrEMBL
      A0A0B4LEY6
      Related
      FBpp0086972
      Conserved Domains (3) summary
      COG1308
      Location:74 → 216
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14358
      Location:179 → 215
      UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes
      pfam01849
      Location:75 → 128
      NAC; NAC domain

    3. NM_134312.3 → NP_599139.1  nascent polypeptide associated complex protein alpha subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZF1, O16813, Q0E999, Q94518
      UniProtKB/TrEMBL
      A0A0B4LEY6
      Related
      FBpp0086973
      Conserved Domains (3) summary
      COG1308
      Location:74 → 216
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14358
      Location:179 → 215
      UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes
      pfam01849
      Location:75 → 128
      NAC; NAC domain

    4. NM_001299434.1 → NP_001286363.1  nascent polypeptide associated complex protein alpha subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZF1, O16813, Q0E999, Q94518
      UniProtKB/TrEMBL
      A0A0B4LEY6
      Conserved Domains (3) summary
      COG1308
      Location:74 → 216
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14358
      Location:179 → 215
      UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes
      pfam01849
      Location:75 → 128
      NAC; NAC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEY6 A0A0B4LEY6
    Q94518.2 Q94518

    Gene LinkOut

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