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    Rpn13 Regulatory particle non-ATPase 13 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36545, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rpn13provided by FlyBase
    Official Full Name
    Regulatory particle non-ATPase 13provided by FlyBase
    Primary source
    FLYBASE:FBgn0033886
    Locus tag
    Dmel_CG13349
    See related
    AllianceGenome:FB:FBgn0033886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13349; Dmel\CG13349; GC13349; p42E; rpn13
    Summary
    Predicted to enable endopeptidase activator activity; proteasome binding activity; and ubiquitin binding activity. Involved in positive regulation of smoothened signaling pathway. Located in cytoplasm and nucleus. Part of proteasome regulatory particle. Is expressed in adult head; adult heart; and organism. Orthologous to human ADRM1 (ADRM1 26S proteasome ubiquitin receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Rpn13 in Genome Data Viewer
    Location:
    50C17-50C18; 2-68 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13958545..13960404, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9846050..9847909, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene DJ-1alpha Neighboring gene Argonaute-1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L53 Neighboring gene Cathepsin L1 Neighboring gene uncharacterized protein Neighboring gene Phenylalanyl-tRNA synthetase, mitochondrial

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables endopeptidase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in proteasome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome regulatory particle, lid subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    regulatory particle non-ATPase 13
    Names
    CG13349-PA
    CG13349-PB
    CG13349-PD
    CG13349-PE
    CG13349-PF
    CG13349-PG
    Rpn13-PA
    Rpn13-PB
    Rpn13-PD
    Rpn13-PE
    Rpn13-PF
    Rpn13-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13958545..13960404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137073.3NP_610917.1  regulatory particle non-ATPase 13, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610917.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZG7, B7YZG8, Q7K2G1, Q86NT4
      Related
      FBpp0086736
      Conserved Domains (2) summary
      cd13314
      Location:18122
      PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
      pfam16550
      Location:235341
      RPN13_C; UCH-binding domain
    2. NM_001144190.2NP_001137662.1  regulatory particle non-ATPase 13, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFA6
      Conserved Domains (2) summary
      cd13314
      Location:18122
      PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
      pfam16550
      Location:267376
      RPN13_C; UCH-binding domain
    3. NM_166025.2NP_725346.1  regulatory particle non-ATPase 13, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZG7, B7YZG8, Q7K2G1, Q86NT4
      Related
      FBpp0086737
      Conserved Domains (2) summary
      cd13314
      Location:18122
      PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
      pfam16550
      Location:235341
      RPN13_C; UCH-binding domain
    4. NM_001144191.2NP_001137663.1  regulatory particle non-ATPase 13, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFA6
      Conserved Domains (2) summary
      cd13314
      Location:18122
      PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
      pfam16550
      Location:267376
      RPN13_C; UCH-binding domain
    5. NM_001144192.2NP_001137664.1  regulatory particle non-ATPase 13, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZG7, B7YZG8, Q7K2G1, Q86NT4
      Conserved Domains (2) summary
      cd13314
      Location:18122
      PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
      pfam16550
      Location:235341
      RPN13_C; UCH-binding domain
    6. NM_001299468.1NP_001286397.1  regulatory particle non-ATPase 13, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286397.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFA6
      Conserved Domains (2) summary
      cd13314
      Location:18122
      PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
      pfam16550
      Location:267376
      RPN13_C; UCH-binding domain