Zdhhc12 zinc finger DHHC-type palmitoyltransferase 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zdhhc12provided by RGD
Official Full Name: zinc finger DHHC-type palmitoyltransferase 12provided by RGD
Primary source: RGD:1306593
See related: EnsemblRapid:ENSRNOG00000015791 AllianceGenome:RGD:1306593
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including gephyrin clustering involved in postsynaptic density assembly; negative regulation of NLRP3 inflammasome complex assembly; and peptidyl-L-cysteine S-palmitoylation. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus; dendritic spine; and endoplasmic reticulum. Orthologous to human ZDHHC12 (zinc finger DHHC-type palmitoyltransferase 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 131.9), Kidney (RPKM 67.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (33761338..33764207, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13363504..13366383, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8656397..8659102, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134692 (e-PCR)
- UniSTS:217971

AI011615 (e-PCR)
- UniSTS:250106

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in gephyrin clustering involved in postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in gephyrin clustering involved in postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in gephyrin clustering involved in postsynaptic density assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, GABAergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC12

Names: DHHC domain-containing cysteine-rich protein 12; DHHC-12; membrane-associated DHHC12 zinc finger protein; probable palmitoyltransferase ZDHHC12; zinc finger DHHC domain-containing protein 12; zinc finger, DHHC domain containing 12; zinc finger, DHHC-type containing 12

NP_001013257.1

EC 2.3.1.225

XP_038961511.1

EC 2.3.1.225

XP_038961512.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013239.1 → NP_001013257.1 palmitoyltransferase ZDHHC12

See identical proteins and their annotated locations for NP_001013257.1

Status: PROVISIONAL

Source sequence(s)

BC076393

UniProtKB/Swiss-Prot

Q2TGJ7, Q6DGF5

UniProtKB/TrEMBL

A0A8L2QLS6, A6JTV1

Related

ENSRNOP00000039802.4, ENSRNOT00000050908.6

Conserved Domains (1) summary

pfam01529
Location:123 → 217

DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

33761338..33764207 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105583.2 → XP_038961511.1 palmitoyltransferase ZDHHC12 isoform X1

Conserved Domains (1) summary

cl19890
Location:156 → 168

DHHC; DHHC palmitoyltransferase
XM_039105584.2 → XP_038961512.1 palmitoyltransferase ZDHHC12 isoform X2

UniProtKB/TrEMBL

A6JTV2

Conserved Domains (1) summary

pfam01529
Location:35 → 129

DHHC; DHHC palmitoyltransferase