Ptk6 protein tyrosine kinase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptk6provided by RGD
Official Full Name: protein tyrosine kinase 6provided by RGD
Primary source: RGD:1309098
See related: EnsemblRapid:ENSRNOG00000012987 AllianceGenome:RGD:1309098
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cellular response to retinoic acid; negative regulation of protein tyrosine kinase activity; and protein phosphorylation. Predicted to be located in cytosol; nuclear body; and ruffle. Predicted to be active in plasma membrane. Orthologous to human PTK6 (protein tyrosine kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 21.2) and Lung (RPKM 1.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (188684633..188693224, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (168307073..168315664, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (176698305..176706896, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brk does not promote proliferation of non-transformed cells, but plays a positive role in the regulation of the apoptotic response to DNA-damage and stress
Title: The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis.
Sam68 suppresses BRK-induced cell proliferation, and regulates intranuclear localization and cell cycle progression
Title: Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in intestinal epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein-tyrosine kinase 6

Names: PTK6 protein tyrosine kinase 6

NP_001102438.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108968.1 → NP_001102438.1 protein-tyrosine kinase 6

See identical proteins and their annotated locations for NP_001102438.1

Status: PROVISIONAL

Source sequence(s)

CH474066

UniProtKB/TrEMBL

A6KM34, D3ZDS3

Related

ENSRNOP00000017337.4, ENSRNOT00000017337.6

Conserved Domains (4) summary

cd10358
Location:75 → 174

SH2_PTK6_Brk; Src homology 2 domain found in protein-tyrosine kinase-6 (PTK6) which is also known as breast tumor kinase (Brk)

cd11847
Location:12 → 69

SH3_Brk; Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called PTK6

smart00221
Location:192 → 441

STYKc; Protein kinase; unclassified specificity

cl21453
Location:184 → 444

PKc_like; Protein Kinases, catalytic domain