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    ckn caskin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36673, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cknprovided by FlyBase
    Official Full Name
    caskinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033987
    Locus tag
    Dmel_CG12424
    See related
    AllianceGenome:FB:FBgn0033987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM06913; CG12424; Dmel\CG12424
    Summary
    Enables protein phosphatase binding activity and signaling adaptor activity. Involved in axon guidance and cell surface receptor protein tyrosine phosphatase signaling pathway. Located in axon; cytoplasm; and focal adhesion. Is expressed in several structures, including clypeo-labral anlage; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and larval imaginal tissue. Orthologous to human CASKIN1 (CASK interacting protein 1); CASKIN2 (CASK interacting protein 2); and OSTF1 (osteoclast stimulating factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ckn in Genome Data Viewer
    Location:
    51D6-51D6; 2-73 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14963292..14980795)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10850797..10868300)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lap1 Neighboring gene uncharacterized protein Neighboring gene atypical protein kinase C Neighboring gene transfer RNA:Leucine-AAG 1-1 Neighboring gene parcas Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. Weng YL, et al. J Neurosci, 2011 Mar 23. PMID 21430143, Free PMC Article
    2. dRTEL1 is essential for the maintenance of Drosophila male germline stem cells. Yang Y, et al. PLoS Genet, 2021 Oct. PMID 34644293, Free PMC Article
    3. FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. Nechipurenko IV, et al. J Cell Biol, 2012 Feb 6. PMID 22312004, Free PMC Article
    4. Drosophila R8 photoreceptor cell subtype specification requires hibris. Tan H, et al. PLoS One, 2020. PMID 33052948, Free PMC Article
    5. A Drosophila RNAi screen reveals conserved glioblastoma-related adhesion genes that regulate collective cell migration. Kotian N, et al. G3 (Bethesda), 2022 Jan 4. PMID 34849760, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila caskin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically with the leukocyte common antigen-related
      Title: The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine phosphatase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine phosphatase signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caskin
    Names
    CG12424-PB
    CG12424-PC
    CG12424-PD
    CG12424-PE
    CG12424-PF
    ckn-PB
    ckn-PC
    ckn-PD
    ckn-PE
    ckn-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14963292..14980795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137165.2 → NP_611009.1  caskin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQG5
      Related
      FBpp0311860
      Conserved Domains (4) summary
      cd09497
      Location:254 → 319
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:320 → 390
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:326 → 387
      SAM; Sterile alpha motif
      pfam16632
      Location:887 → 912
      Caskin-tail; C-terminal region of Caskin

    2. NM_166077.2 → NP_725434.1  caskin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQG5
      Related
      FBpp0086540
      Conserved Domains (4) summary
      cd09497
      Location:254 → 319
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:320 → 390
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:326 → 387
      SAM; Sterile alpha motif
      pfam16632
      Location:887 → 912
      Caskin-tail; C-terminal region of Caskin

    3. NM_001299508.1 → NP_001286437.1  caskin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFD7
      Conserved Domains (4) summary
      cd09497
      Location:254 → 319
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:320 → 390
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:326 → 387
      SAM; Sterile alpha motif
      pfam16632
      Location:808 → 833
      Caskin-tail; C-terminal region of Caskin

    4. NM_166076.2 → NP_725433.1  caskin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725433.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQG5
      Related
      FBpp0086542
      Conserved Domains (4) summary
      cd09497
      Location:254 → 319
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:320 → 390
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:326 → 387
      SAM; Sterile alpha motif
      pfam16632
      Location:887 → 912
      Caskin-tail; C-terminal region of Caskin

    5. NM_001299509.1 → NP_001286438.1  caskin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF60
      Conserved Domains (3) summary
      cd09498
      Location:45 → 108
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:46 → 105
      SAM; Sterile alpha motif
      pfam16632
      Location:605 → 630
      Caskin-tail; C-terminal region of Caskin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF60 A0A0B4LF60
    A0A0B4LFD7 A0A0B4LFD7
    Q7JQG5 Q7JQG5
    Q8T948 Q8T948

    Gene LinkOut

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