Gadl1 glutamate decarboxylase-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gadl1provided by RGD
Full Name: glutamate decarboxylase-like 1provided by RGD
Primary source: RGD:1565145
See related: EnsemblRapid:ENSRNOG00000067908 AllianceGenome:RGD:1565145
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565145
Summary: Predicted to enable carboxy-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in carboxylic acid metabolic process. Orthologous to human GADL1 (glutamate decarboxylase like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 185.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (124483736..124663815)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (115605609..115785676)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (123989822..124301366)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D8Got190 (e-PCR)
- UniSTS:114450

d8rat119 (e-PCR)
- UniSTS:122402

D8Got189 (e-PCR)
- UniSTS:112680

AU026401 (e-PCR)
- UniSTS:114316

AU049970 (e-PCR)
- UniSTS:146412

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acidic amino acid decarboxylase GADL1; glutamate decarboxylase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430390.1 → NP_001417319.1 glutamate decarboxylase-like 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6AWC8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

124483736..124663815

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766660.4 → XP_008764882.3 acidic amino acid decarboxylase GADL1 isoform X1

Related

ENSRNOP00000102931.1, ENSRNOT00000172052.1

Conserved Domains (1) summary

cd06450
Location:196 → 596

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_039082694.2 → XP_038938622.1 acidic amino acid decarboxylase GADL1 isoform X2

UniProtKB/TrEMBL

A0A8I6AWC8

Conserved Domains (1) summary

cd06450
Location:98 → 498

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_039082695.2 → XP_038938623.1 acidic amino acid decarboxylase GADL1 isoform X2

UniProtKB/TrEMBL

A0A8I6AWC8

Related

ENSRNOP00000097428.2, ENSRNOT00000117193.2

Conserved Domains (1) summary

cd06450
Location:98 → 498

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...