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    Jheh2 Juvenile hormone epoxide hydrolase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jheh2provided by FlyBase
    Official Full Name
    Juvenile hormone epoxide hydrolase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034405
    Locus tag
    Dmel_CG15102
    See related
    AllianceGenome:FB:FBgn0034405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15102; CT34977; DmEH; Dmel\CG15102; JHEH 2; jheh2
    Summary
    Enables serine hydrolase activity. Predicted to be involved in epoxide metabolic process and juvenile hormone catabolic process. Is expressed in several structures, including adult head; adult heart; embryonic proventriculus inner layer; embryonic/larval oenocyte; and gut section. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jheh2 in Genome Data Viewer
    Location:
    55F8-55F8; 2-86 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18855767..18858245, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14743272..14745750, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46485 Neighboring gene Juvenile hormone epoxide hydrolase 1 Neighboring gene Juvenile hormone epoxide hydrolase 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster. Taniai K, et al. Eur J Biochem, 2003 Dec. PMID 14622257
    2. Microsomal and cytosolic epoxide hydrolase in Drosophila melanogaster. Jansen M, et al. Biochem Pharmacol, 1986 Jul 1. PMID 3089226
    3. A recent adaptive transposable element insertion near highly conserved developmental loci in Drosophila melanogaster. González J, et al. Mol Biol Evol, 2009 Sep. PMID 19458110, Free PMC Article
    4. The transposable element Bari-Jheh mediates oxidative stress response in Drosophila. Guio L, et al. Mol Ecol, 2014 Apr. PMID 24629106
    5. The dominance effect of the adaptive transposable element insertion Bari-Jheh depends on the genetic background. Guio L, et al. Genome Biol Evol, 2015 Apr 24. PMID 25912044, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cDNA cloning and characterization
      Title: Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables epoxide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ether hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables juvenile hormone epoxide hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in epoxide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in juvenile hormone catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    juvenile hormone epoxide hydrolase 2
    Names
    CG15102-PA
    CG15102-PD
    Jheh2-PA
    Jheh2-PD
    juvenile hormone esterase
    NP_611386.2
    NP_788413.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18855767..18858245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176233.4 → NP_788413.4  juvenile hormone epoxide hydrolase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788413.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBF3, Q7KB18, Q8SZM7
      Conserved Domains (3) summary
      pfam00561
      Location:156 → 370
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam06441
      Location:58 → 165
      EHN; Epoxide hydrolase N terminus
      cl21494
      Location:111 → 251
      Abhydrolase; alpha/beta hydrolases

    2. NM_137542.4 → NP_611386.2  juvenile hormone epoxide hydrolase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611386.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBF3, Q7KB18, Q8SZM7
      Related
      FBpp0088908
      Conserved Domains (3) summary
      pfam00561
      Location:156 → 370
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam06441
      Location:58 → 165
      EHN; Epoxide hydrolase N terminus
      cl21494
      Location:111 → 251
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KB18 Q7KB18
    Q8SZM7 Q8SZM7

    Gene LinkOut

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