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    VAV2 vav guanine nucleotide exchange factor 2 [ Gallus gallus (chicken) ]

    Gene ID: 373938, updated on 3-Dec-2024

    Summary

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    Symbol
    VAV2provided by CGNC
    Full Name
    vav guanine nucleotide exchange factor 2provided by CGNC
    Primary source
    CGNC:1945
    See related
    Ensembl:ENSGALG00010028884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See VAV2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (7654387..7754756, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (7065985..7165871, complement)

    Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene ADAMTS like 2 Neighboring gene family with sequence similarity 163 member B Neighboring gene dopamine beta-hydroxylase Neighboring gene sarcosine dehydrogenase Neighboring gene uncharacterized LOC100858426 Neighboring gene bromodomain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. Inabe K, et al. J Exp Med, 2002 Jan 21. PMID 11805146, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor VAV2
    Names
    vav 2 guanine nucleotide exchange factor
    vav 2 oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204142.2 → NP_989473.2  guanine nucleotide exchange factor VAV2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000308
      UniProtKB/TrEMBL
      Q8UUX5
      Related
      ENSGALP00010042985.1, ENSGALT00010069859.1
      Conserved Domains (7) summary
      cd10406
      Location:657 → 759
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:780 → 837
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580 → 639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:197 → 370
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01223
      Location:384 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      cd21263
      Location:2 → 120
      CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
      cd20868
      Location:509 → 566
      C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      7654387..7754756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046901616.1 → XP_046757572.1  guanine nucleotide exchange factor VAV2 isoform X3

      UniProtKB/TrEMBL
      Q8UUX5
      Related
      ENSGALP00010042982.1, ENSGALT00010069856.1

    2. XM_046901615.1 → XP_046757571.1  guanine nucleotide exchange factor VAV2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1AK54

    3. XM_046901614.1 → XP_046757570.1  guanine nucleotide exchange factor VAV2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1AK54

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      7065985..7165871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials