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    eEFSec eukaryotic translation elongation factor, selenocysteine-specific [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eEFSecprovided by FlyBase
    Official Full Name
    eukaryotic translation elongation factor, selenocysteine-specificprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034627
    Locus tag
    Dmel_CG9841
    See related
    AllianceGenome:FB:FBgn0034627
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9841; deEFsec; dEFsec; Dmel\CG9841; eEFsec; Efsec; EfSec; EFsec; EFSec; Eftu; SelB/eEFsec
    Summary
    Enables GTPase activating protein binding activity. Involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Orthologous to human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eEFSec in Genome Data Viewer
    Location:
    57E1-57E1; 2-95 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21384552..21386221, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17272057..17273726, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene crossveinless 2 Neighboring gene acyl-Coenzyme A oxidase at 57D proximal Neighboring gene acyl-Coenzyme A oxidase at 57D distal Neighboring gene biscotti Neighboring gene Syndecan

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Decoding apparatus for eukaryotic selenocysteine insertion. Tujebajeva RM, et al. EMBO Rep, 2000 Aug. PMID 11265756, Free PMC Article
    2. Conserved selenoprotein synthesis is not critical for oxidative stress defence and the lifespan of Drosophila. Hirosawa-Takamori M, et al. EMBO Rep, 2004 Mar. PMID 14978508, Free PMC Article
    3. Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance. Shchedrina VA, et al. J Biol Chem, 2011 Aug 26. PMID 21622567, Free PMC Article
    4. Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Lobanov AV, et al. Protein Sci, 2008 Jan. PMID 18156471, Free PMC Article
    5. A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila. Hirosawa-Takamori M, et al. FASEB J, 2009 Jan. PMID 18772345, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila mutants that lack the translation elongation factor SelB/eEFsec fail to decode the UGA codon as selenocysteine, but they are viable and fertile.
      Title: Conserved selenoprotein synthesis is not critical for oxidative stress defence and the lifespan of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in selenocysteine incorporation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational readthrough IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation elongation factor, selenocysteine-specific
    Names
    CG9841-PA
    EfSec
    eEFSec-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21384552..21386221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137740.3 → NP_611584.1  eukaryotic translation elongation factor, selenocysteine-specific [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2H0
      Related
      FBpp0071534
      Conserved Domains (4) summary
      cd01889
      Location:5 → 192
      SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
      COG3276
      Location:6 → 467
      SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]
      cd03696
      Location:196 → 278
      SelB_II; Domain II of elongation factor SelB
      cd04094
      Location:283 → 396
      eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2H0 Q9W2H0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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