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    Chrac-14 Chromatin accessibility complex 14kD protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772329, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Chrac-14provided by FlyBase
    Official Full Name
    Chromatin accessibility complex 14kD proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043002
    Locus tag
    Dmel_CG13399
    See related
    AllianceGenome:FB:FBgn0043002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    13399; 18K protein; 55A11T; CG13399; CG32956; CHRAC; chrac-14; CHRAC-14; Chrac14; CHRAC14; dChrac14; Dmel\CG13399; ESTS:55A11T; mary; PolE3
    Summary
    Predicted to enable chromatin DNA binding activity. Involved in CENP-A containing chromatin assembly; DNA damage response; and cellular response to gamma radiation. Part of ATAC complex and CHRAC. Is expressed in several structures, including antennal anlage; antennal primordium; anterior endoderm; anterior endoderm anlage; and head epidermis primordium. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Chrac-14 in Genome Data Viewer
    Location:
    29C4-29C4; 2-32 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8437405..8437996)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8437405..8437996)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 200 Neighboring gene gurken Neighboring gene D12 Neighboring gene mutagen-sensitive 201 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions. Hartlepp KF, et al. Mol Cell Biol, 2005 Nov. PMID 16260604, Free PMC Article
    2. The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding. Bonaldi T, et al. EMBO J, 2002 Dec 16. PMID 12486007, Free PMC Article
    3. Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II. Varga-Weisz PD, et al. Nature, 1997 Aug 7. PMID 9252192
    4. Acf1, the largest subunit of CHRAC, regulates ISWI-induced nucleosome remodelling. Eberharter A, et al. EMBO J, 2001 Jul 16. PMID 11447119, Free PMC Article
    5. The histone-fold protein CHRAC14 influences chromatin composition in response to DNA damage. Mathew V, et al. Cell Rep, 2014 Apr 24. PMID 24703848

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CHRAC14 modulates chromatin composition in response to DNA damage.
      Title: The histone-fold protein CHRAC14 influences chromatin composition in response to DNA damage.
    2. X-ray crystallographic structure of Drosophila melanogaster CHRAC14-CHRAC16 dimer
      Title: The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in CENP-A containing chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATAC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of CHRAC IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CHRAC IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of epsilon DNA polymerase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    chromatin accessibility complex 14kD protein
    Names
    CG13399-PB
    Chrac-14-PB
    DNA polymerase epsilon subunit 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8437405..8437996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057298.4 → NP_476646.2  chromatin accessibility complex 14kD protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476646.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V444
      Conserved Domains (1) summary
      cl23735
      Location:6 → 93
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V444.1 Q9V444

    Gene LinkOut

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