itgb6.L integrin subunit beta 6 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: itgb6.L
Official Full Name: integrin subunit beta 6 L homeolog
Primary source: Xenbase:XB-GENE-960437
Locus tag: XELAEV_18044618mg
See related: EnsemblRapid:ENSXLAG00005022044 AllianceGenome:Xenbase:XB-GENE-960437
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: XBX6; itgb6; itgb6-A
Summary: Predicted to act upstream of or within cell adhesion and integrin-mediated signaling pathway. Predicted to be located in focal adhesion and plasma membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Orthologous to human ITGB6 (integrin subunit beta 6). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (71486265..71551977, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (60975076..61012304, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin beta-6

Names: integrin beta-6 subunit; integrin, beta 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

71486265..71551977 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041577103.1 → XP_041433037.1 integrin beta-6 isoform X1

UniProtKB/TrEMBL

A0A1L8EW13, A0A974BZ39

Conserved Domains (5) summary

smart00187
Location:30 → 454

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:619 → 701

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:726 → 769

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:454 → 483

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:488 → 628

exchanger_TraA; outer membrane exchange protein TraA
XM_018235840.2 → XP_018091329.1 integrin beta-6 isoform X2

UniProtKB/TrEMBL

A0A8J0TUZ1
XM_018235839.2 → XP_018091328.1 integrin beta-6 isoform X1

UniProtKB/TrEMBL

A0A1L8EW13, A0A974BZ39

Related

ENSXLAP00005064736.1, ENSXLAT00005066250.1

Conserved Domains (5) summary

smart00187
Location:30 → 454

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:619 → 701

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:726 → 769

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:454 → 483

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:488 → 628

exchanger_TraA; outer membrane exchange protein TraA
XM_018235841.2 → XP_018091330.1 integrin beta-6 isoform X3

UniProtKB/TrEMBL

A0A8J0TW44
XM_041577105.1 → XP_041433039.1 integrin beta-6 isoform X4

UniProtKB/TrEMBL

A0A8J1LUL9

Conserved Domains (1) summary

cl00057
Location:1 → 316

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...