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    Kcnh4 potassium voltage-gated channel, subfamily H (eag-related), member 4 [ Mus musculus (house mouse) ]

    Gene ID: 380728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnh4provided by MGI
    Official Full Name
    potassium voltage-gated channel, subfamily H (eag-related), member 4provided by MGI
    Primary source
    MGI:MGI:2156184
    See related
    Ensembl:ENSMUSG00000035355 AllianceGenome:MGI:2156184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BEC2
    Summary
    Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to be active in plasma membrane. Orthologous to human KCNH4 (potassium voltage-gated channel subfamily H member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 10.0), CNS E18 (RPKM 9.3) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnh4 in Genome Data Viewer
    Location:
    11 D; 11 63.57 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100631204..100650941, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100740378..100760115, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100575167-100575276 Neighboring gene heat shock protein, alpha-crystallin-related, B9 Neighboring gene RAB5C, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E3022 Neighboring gene STARR-positive B cell enhancer ABC_E8452 Neighboring gene hypocretin Neighboring gene STARR-positive B cell enhancer ABC_E5278 Neighboring gene GH3 domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Cui Y, et al. Genomics, 2001 Dec. PMID 11735219
    2. A gene expression resource generated by genome-wide lacZ profiling in the mouse. Tuck E, et al. Dis Model Mech, 2015 Nov. PMID 26398943, Free PMC Article
    3. Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Wang N, et al. Neuron, 2022 Oct 19. PMID 36265442, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily H member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081194.2 → NP_001074663.1  potassium voltage-gated channel subfamily H member 4

      See identical proteins and their annotated locations for NP_001074663.1

      Status: VALIDATED

      Source sequence(s)
      AL591469, BC150990
      Consensus CDS
      CCDS36334.1
      UniProtKB/TrEMBL
      A2A5F7
      Related
      ENSMUSP00000102984.2, ENSMUST00000107361.9
      Conserved Domains (6) summary
      cd00038
      Location:556 → 676
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:42 → 133
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:244 → 486
      Ion_trans; Ion transport protein
      pfam07885
      Location:426 → 480
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 135
      PAS_9; PAS domain
      cl21462
      Location:864 → 902
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100631204..100650941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533646.4 → XP_006533709.1  potassium voltage-gated channel subfamily H member 4 isoform X1

      Conserved Domains (3) summary
      PLN03192
      Location:177 → 620
      PLN03192; Voltage-dependent potassium channel; Provisional
      PRK11753
      Location:583 → 671
      PRK11753; cAMP-activated global transcriptional regulator CRP
      PRK13557
      Location:41 → 134
      PRK13557; histidine kinase; Provisional

    2. XM_036156819.1 → XP_036012712.1  potassium voltage-gated channel subfamily H member 4 isoform X2

      Conserved Domains (4) summary
      PLN03192
      Location:61 → 255
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03247
      Location:347 → 638
      PHA03247; large tegument protein UL36; Provisional
      cl00047
      Location:213 → 304
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl21462
      Location:499 → 537
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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