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    Plpp4 phospholipid phosphatase 4 [ Mus musculus (house mouse) ]

    Gene ID: 381925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plpp4provided by MGI
    Official Full Name
    phospholipid phosphatase 4provided by MGI
    Primary source
    MGI:MGI:2685936
    See related
    Ensembl:ENSMUSG00000070366 AllianceGenome:MGI:2685936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1090; Ppapdc1a; C030048B12Rik
    Summary
    Predicted to enable diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Acts upstream of or within blastocyst hatching. Predicted to be active in membrane. Is expressed in early conceptus and secondary oocyte. Orthologous to human PLPP4 (phospholipid phosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 3.6), CNS E18 (RPKM 3.6) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plpp4 in Genome Data Viewer
    Location:
    7 F3; 7 71.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (128858114..128993138)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (129256390..129391412)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Rho family GTPase 2 pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_20220 Neighboring gene STARR-seq mESC enhancer starr_20221 Neighboring gene STARR-seq mESC enhancer starr_20222 Neighboring gene STARR-seq mESC enhancer starr_20226 Neighboring gene predicted gene, 33027 Neighboring gene STARR-seq mESC enhancer starr_20231 Neighboring gene STARR-seq mESC enhancer starr_20232 Neighboring gene STARR-seq mESC enhancer starr_20233 Neighboring gene STARR-seq mESC enhancer starr_20234 Neighboring gene STARR-positive B cell enhancer mm9_chr7:136735231-136735532 Neighboring gene WD repeat domain 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables diacylglycerol diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables diacylglycerol diphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium ion import ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase 4
    Names
    phosphatidate phosphatase PPAPDC1A
    phosphatidic acid phosphatase type 2 domain containing 1A
    phosphatidic acid phosphatase type 2 domain-containing protein 1A
    NP_001074432.1
    NP_001406315.1
    NP_001406316.1
    NP_001406317.1
    NP_001406318.1
    NP_001406319.1
    NP_001406320.1
    XP_017177812.1
    XP_030098589.1
    XP_036009094.1
    XP_036009096.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080963.2 → NP_001074432.1  phospholipid phosphatase 4 isoform 1

      See identical proteins and their annotated locations for NP_001074432.1

      Status: VALIDATED

      Source sequence(s)
      AC100956, AC109182
      Consensus CDS
      CCDS40154.1
      UniProtKB/Swiss-Prot
      Q0VBU9
      Related
      ENSMUSP00000091557.5, ENSMUST00000094018.6
      Conserved Domains (1) summary
      cd03390
      Location:37 → 225
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    2. NM_001419386.1 → NP_001406315.1  phospholipid phosphatase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC100956, AC109182

    3. NM_001419387.1 → NP_001406316.1  phospholipid phosphatase 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC100956, AC109182

    4. NM_001419388.1 → NP_001406317.1  phospholipid phosphatase 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC100956, AC109182

    5. NM_001419389.1 → NP_001406318.1  phospholipid phosphatase 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC100956, AC109182

    6. NM_001419390.1 → NP_001406319.1  phospholipid phosphatase 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC100956, AC109182

    7. NM_001419391.1 → NP_001406320.1  phospholipid phosphatase 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC100956, AC109182

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      128858114..128993138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322323.3 → XP_017177812.1  phospholipid phosphatase 4 isoform X1

      Conserved Domains (1) summary
      cd03390
      Location:37 → 224
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    2. XM_036153203.1 → XP_036009096.1  phospholipid phosphatase 4 isoform X5

      Conserved Domains (1) summary
      cl00474
      Location:37 → 167
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

    3. XM_030242729.2 → XP_030098589.1  phospholipid phosphatase 4 isoform X7

      Conserved Domains (1) summary
      cd03390
      Location:7 → 104
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    4. XM_036153201.1 → XP_036009094.1  phospholipid phosphatase 4 isoform X3

      Conserved Domains (1) summary
      cd03390
      Location:1 → 171
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VBU9.1 GenPept UniProtKB/Swiss-Prot:Q0VBU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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