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    mv mauve [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mvprovided by FlyBase
    Official Full Name
    mauveprovided by FlyBase
    Primary source
    FLYBASE:FBgn0288310
    Locus tag
    Dmel_CG42863
    See related
    AllianceGenome:FB:FBgn0288310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11814; CG42863; CG5691; Dmel\CG42863; fs(3)ros; ros
    Old locus tag
    Dmel_CG11814; Dmel_CG5691
    Summary
    Involved in negative regulation of autophagosome size; phagocytosis; and regulation of organelle organization. Located in spindle pole and vesicle. Is expressed in adult head and organism. Used to study Chediak-Higashi syndrome. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    62B11-62B12; 3-1.0 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1950306..1964178, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1950306..1964178, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Microfibril-associated protein 1 Neighboring gene mutator 2 Neighboring gene Centrobin Neighboring gene antisense RNA:CR45827 Neighboring gene antisense RNA:CR45828 Neighboring gene Succinyl-CoA:3-ketoacid CoA transferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila embryos spatially sort their nutrient stores to facilitate their utilization. Kilwein MD, et al. Development, 2023 Oct 15. PMID 36805634, Free PMC Article
    2. Serine protease MP2 activates prophenoloxidase in the melanization immune response of Drosophila melanogaster. An C, et al. PLoS One, 2013. PMID 24260243, Free PMC Article
    3. Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster. Kasravi A, et al. Genetics, 1999 Jul. PMID 10388821, Free PMC Article
    4. Drosophila mauve mutants reveal a role of LYST homologs late in the maturation of phagosomes and autophagosomes. Rahman M, et al. Traffic, 2012 Dec. PMID 22934826, Free PMC Article
    5. Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins. Lattao R, et al. Dev Cell, 2021 Apr 5. PMID 33725482, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins.
      Title: Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of autophagosome size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mauve
    Names
    CG42863-PB
    mv-PB
    rosario

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1950306..1964178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139424.2 → NP_647681.2  mauve [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647681.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W060
      Conserved Domains (3) summary
      smart01026
      Location:2796 → 3080
      Beach; Beige/BEACH domain
      cl17171
      Location:2704 → 2785
      PH-like; Pleckstrin homology-like domain
      cl29593
      Location:3308 → 3507
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W060.2 Q9W060

    Gene LinkOut

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