ImpL2 Ecdysone-inducible gene L2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ImpL2provided by FlyBase
Official Full Name: Ecdysone-inducible gene L2provided by FlyBase
Primary source: FLYBASE:FBgn0001257
Locus tag: Dmel_CG15009
See related: AllianceGenome:FB:FBgn0001257
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15009; CT34862; Dmel\CG15009; GH28; Imp-12; imp-L2; Imp-L2; IMP-L2; ImpL-2; impl2; impL2; Impl2; IMPL2
Summary: Enables insulin binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of entry into reproductive diapause; and regulation of insulin receptor signaling pathway. Located in extracellular space. Is expressed in several structures, including CNS glial cell; anterior-posterior subdivision of organism; follicle cell; gut section; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64A10-64A10; 3-10 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4224006..4236147, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4224006..4236147, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-alpha/egr and ImpL2 signaling in Drosophila larvae.
Title: Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae.
Piwi expressed in Drosophila adipose tissues regulates systemic IGF signaling and growth via IGF-binding protein.
Title: Piwi expressed in Drosophila adipose tissues regulates systemic IGF signaling and growth via IGF-binding protein.
Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection.
Title: Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection.
Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling.
Title: Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling.
Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless.
Title: Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless.
beta-sheet fold serves as a direct, high-affinity binder of hormones; likely represents an alternative hormone binding and regulatory IBP system different and evolutionarily independent from human IGFBPs
Title: Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
Increased expression of ImpL2 is associated with cachexia-like wasting.
Title: Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting.
Increased expression of the secreted insulin/IGF antagonist ImpL2 is associated with organ wasting.
Title: Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2.
Imp-L2-expressing neurons sense the nutritional state of Drosophila larvae and coordinate dietary information and ecdysone production to adjust developmental timing under starvation conditions
Title: Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions.
role in the longevity
Title: Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables insulin binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of entry into reproductive diapause	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in response to insect	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ecdysone-inducible gene L2

Names: CG15009-PA; CG15009-PB; CG15009-PC; CG15009-PD; ImpL2-PA; ImpL2-PB; ImpL2-PC; ImpL2-PD; ecdysone-inducible gene L2; imaginal morphogenesis protein-late 2; neural and ectodermal development factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

4224006..4236147 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274480.1 → NP_001261409.1 Ecdysone-inducible gene L2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261409.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEL7, Q3YMW0

Conserved Domains (1) summary

smart00408
Location:183 → 247

IGc2; Immunoglobulin C-2 Type
NM_079197.5 → NP_523921.3 Ecdysone-inducible gene L2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523921.3

Status: REVIEWED

UniProtKB/TrEMBL

Q3YMW0

Related

FBpp0073104

Conserved Domains (1) summary

smart00408
Location:186 → 250

IGc2; Immunoglobulin C-2 Type
NM_168069.2 → NP_728960.1 Ecdysone-inducible gene L2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728960.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEL7, Q3YMW0

Related

FBpp0073105

Conserved Domains (1) summary

smart00408
Location:183 → 247

IGc2; Immunoglobulin C-2 Type
NM_168070.2 → NP_728961.2 Ecdysone-inducible gene L2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728961.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09024, Q6NLN1, Q7KV52, Q95SU7, Q9VZF7

UniProtKB/TrEMBL

Q3YMW0

Related

FBpp0073106

Conserved Domains (1) summary

smart00408
Location:187 → 251

IGc2; Immunoglobulin C-2 Type