U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Galk Galactokinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39031, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Galkprovided by FlyBase
    Official Full Name
    Galactokinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263199
    Locus tag
    Dmel_CG5288
    See related
    AllianceGenome:FB:FBgn0263199
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg5288; CG5288; CT16885; dGALK; Dmel\CG5288; GALK
    Summary
    Enables galactokinase activity. Involved in UDP-galactose biosynthetic process and galactose catabolic process via UDP-galactose. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic Malpighian tubule; and gut section. Orthologous to human GALK2 (galactokinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Galk in Genome Data Viewer
    Location:
    66F1-66F1; 3-28 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8982212..8986091, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8975312..8979191, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pixie Neighboring gene Signal recognition particle 68 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene smaug

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. GALDAR: A genetically encoded galactose sensor for visualizing sugar metabolism in vivo. Sakizli U, et al. PLoS Biol, 2024 Mar. PMID 38502638, Free PMC Article
    2. UDP-galactose 4' epimerase (GALE) is essential for development of Drosophila melanogaster. Sanders RD, et al. Dis Model Mech, 2010 Sep-Oct. PMID 20519568, Free PMC Article
    3. Acute and long-term outcomes in a Drosophila melanogaster model of classic galactosemia occur independently of galactose-1-phosphate accumulation. Daenzer JM, et al. Dis Model Mech, 2016 Nov 1. PMID 27562100, Free PMC Article
    4. A Drosophila melanogaster model of classic galactosemia. Kushner RF, et al. Dis Model Mech, 2010 Sep-Oct. PMID 20519569, Free PMC Article
    5. Coordinated movement, neuromuscular synaptogenesis and trans-synaptic signaling defects in Drosophila galactosemia models. Jumbo-Lucioni PP, et al. Hum Mol Genet, 2016 Sep 1. PMID 27466186, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Galactokinase is a previously unknown regulator of calcineurin-induced cardiomyopathy in adult Drosophila.
      Title: Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactokinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-galactose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose catabolic process via UDP-galactose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    galactokinase
    Names
    CG5288-PA
    CG5288-PB
    CG5288-PC
    CG5288-PD
    Galk-PA
    Galk-PB
    Galk-PC
    Galk-PD
    NP_001189074.1
    NP_648276.1
    NP_729438.1
    NP_729439.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8982212..8986091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168307.3 → NP_729438.1  galactokinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U34, Q9VSS5
      Related
      FBpp0076280
      Conserved Domains (3) summary
      PLN02521
      Location:32 → 485
      PLN02521; galactokinase
      pfam08544
      Location:385 → 457
      GHMP_kinases_C; GHMP kinases C terminal
      pfam10509
      Location:39 → 88
      GalKase_gal_bdg; Galactokinase galactose-binding signature

    2. NM_140019.4 → NP_648276.1  galactokinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648276.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U34, Q9VSS5
      Related
      FBpp0076281
      Conserved Domains (3) summary
      PLN02521
      Location:32 → 485
      PLN02521; galactokinase
      pfam08544
      Location:385 → 457
      GHMP_kinases_C; GHMP kinases C terminal
      pfam10509
      Location:39 → 88
      GalKase_gal_bdg; Galactokinase galactose-binding signature

    3. NM_001202145.1 → NP_001189074.1  galactokinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U34, Q9VSS5
      Conserved Domains (3) summary
      PLN02521
      Location:32 → 485
      PLN02521; galactokinase
      pfam08544
      Location:385 → 457
      GHMP_kinases_C; GHMP kinases C terminal
      pfam10509
      Location:39 → 88
      GalKase_gal_bdg; Galactokinase galactose-binding signature

    4. NM_168308.3 → NP_729439.1  galactokinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729439.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U34, Q9VSS5
      Related
      FBpp0076282
      Conserved Domains (3) summary
      PLN02521
      Location:32 → 485
      PLN02521; galactokinase
      pfam08544
      Location:385 → 457
      GHMP_kinases_C; GHMP kinases C terminal
      pfam10509
      Location:39 → 88
      GalKase_gal_bdg; Galactokinase galactose-binding signature
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95U34 Q95U34

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools