LanB2 Laminin B2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: LanB2provided by FlyBase
Official Full Name: Laminin B2provided by FlyBase
Primary source: FLYBASE:FBgn0267348
Locus tag: Dmel_CG3322
See related: AllianceGenome:FB:FBgn0267348
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:fe2H3; CG3322; CT11145; Dmel\CG3322; DROLAMB2A; gamma1; knod; l(3)67BDb; Lam-B2; lamB2; LAMB2A; laminin; lanB2; LM-B2/gamma; LMG1; Lmgamma1
Summary: Involved in several processes, including basement membrane assembly; digestive tract development; and substrate adhesion-dependent cell spreading. Located in basement membrane. Is expressed in several structures, including adult head; germ layer; glial cell; hemocyte; and nerve. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to several human genes including LAMC1 (laminin subunit gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 67C2-67C2; 3-31 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9614914..9623980)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9608014..9617080)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that loss of the laminin gamma subunit (LanB2) in the peripheral glia of Drosophila melanogaster results in the disruption of glial morphology due to disruption of laminin secretion
Title: Accumulation of Laminin Monomers in Drosophila Glia Leads to Glial Endoplasmic Reticulum Stress and Disrupted Larval Locomotion.
The data, concerning the different function of laminin B2 during organogenesis, suggest that laminin B2 might act in a cumulative way and probably at multiple steps during extracellular matrix assembly.
Title: The role of LamininB2 (LanB2) during mesoderm differentiation in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in basement membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in endodermal digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: laminin B2

Names: CG3322-PA; CG3322-PB; LamininB2; LanB2-PA; LanB2-PB; anon-fast-evolving-2H3; knodel; laminin; laminin B2 subunit; laminin gamma; laminin gamma 1; laminin gamma-chain; laminin gamma1; laminin gamma2; lamininB; lethal (3) 67BDb

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9614914..9623980

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079282.2 → NP_524006.1 laminin B2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524006.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P15215, Q24373, Q5BI30, Q9VT18

UniProtKB/TrEMBL

X2JAW6

Related

FBpp0076111

Conserved Domains (11) summary

cl14654
Location:1122 → 1443

V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains

smart00136
Location:61 → 296

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:414 → 458

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:572 → 697

LamB; Laminin B domain

COG0840
Location:1139 → 1521

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

cd00055
Location:743 → 791

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00185
Location:724 → 771

TNFRSF; CRD2 [structural motif]

pfam00053
Location:956 → 1004

Laminin_EGF; Laminin EGF domain

cl12013
Location:1308 → 1469

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl22855
Location:721 → 848

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

cl23750
Location:1474 → 1629

vATP-synt_E; ATP synthase (E/31 kDa) subunit
NM_001300080.1 → NP_001287009.1 laminin B2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287009.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P15215, Q24373, Q5BI30, Q9VT18

UniProtKB/TrEMBL

X2JAW6

Conserved Domains (11) summary

cl14654
Location:1122 → 1443

V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains

smart00136
Location:61 → 296

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:414 → 458

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:572 → 697

LamB; Laminin B domain

COG0840
Location:1139 → 1521

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

cd00055
Location:743 → 791

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00185
Location:724 → 771

TNFRSF; CRD2 [structural motif]

pfam00053
Location:956 → 1004

Laminin_EGF; Laminin EGF domain

cl12013
Location:1308 → 1469

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl22855
Location:721 → 848

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

cl23750
Location:1474 → 1629

vATP-synt_E; ATP synthase (E/31 kDa) subunit