lin28ab lin-28 homolog Ab [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lin28abprovided by ZNC
Official Full Name: lin-28 homolog Abprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-747
See related: Ensembl:ENSDARG00000016999 AllianceGenome:ZFIN:ZDB-GENE-040426-747
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lin28; lin28a; sb:cb650; zgc:55584
Summary: Predicted to enable mRNA binding activity. Acts upstream of or within chordate embryonic development; negative regulation of gene expression; and regeneration. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Kupffer's vesicle; central nervous system; digestive system; neural plate; and neural tube. Orthologous to human LIN28A (lin-28 homolog A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (15441101..15472613)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (15537030..15568253)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dual regulation of lin28a by Myc is necessary during zebrafish retina regeneration.
Title: Dual regulation of lin28a by Myc is necessary during zebrafish retina regeneration.
The knockdown of Lin-28a or Lin-28b function by morpholino microinjection into embryos resulted in severe cell proliferation defects during early morphogenesis.
Title: The heterochronic genes lin-28a and lin-28b play an essential and evolutionarily conserved role in early zebrafish development.
The Lin-28 is induced in Muller glia within 6 h following retinal injury and is necessary for Muller glia dedifferentiation.
Title: Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in pre-miRNA processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in rough endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein lin-28 homolog A

Names: RNA-binding protein lin-28; lin-28A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201091.1 → NP_957385.1 protein lin-28 homolog A

See identical proteins and their annotated locations for NP_957385.1

Status: PROVISIONAL

Source sequence(s)

BC044433

UniProtKB/Swiss-Prot

Q1LXL3, Q803L0

Related

ENSDARP00000089741.5, ENSDART00000098970.7

Conserved Domains (1) summary

cd04458
Location:36 → 105

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

15441101..15472613

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009294134.4 → XP_009292409.1 protein lin-28 homolog A isoform X2

See identical proteins and their annotated locations for XP_009292409.1

UniProtKB/TrEMBL

A0A8M3AKW1, I3IS11

Related

ENSDARP00000148718.1, ENSDART00000182329.1

Conserved Domains (1) summary

cd04458
Location:28 → 97

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_005159535.5 → XP_005159592.1 protein lin-28 homolog A isoform X1

UniProtKB/TrEMBL

A0A2R8Q8W5, A0A8M2B642

Related

ENSDARP00000150782.1, ENSDART00000193355.1

Conserved Domains (1) summary

cd04458
Location:41 → 110

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...