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    dlx3.S distal-less homeobox 3 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 394327, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dlx3.S
    Official Full Name
    distal-less homeobox 3 S homeolog
    Primary source
    Xenbase:XB-GENE-6254455
    Locus tag
    XELAEV_18046036mg
    See related
    EnsemblRapid:ENSXLAG00005032093 AllianceGenome:Xenbase:XB-GENE-6254455
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    ai4; tdo; dlx3; xdlx3; X-DLL2; Xdll-2; dlx3-a; dlx3-b
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in dermal system; ectoderm; musculoskeletal system; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See dlx3.S in Genome Data Viewer
    Location:
    chromosome: 9_10S
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (4539235..4547354, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (4412362..4420254, complement)

    Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene distal-less homeobox 4 S homeolog Neighboring gene uncharacterized LOC108702533 Neighboring gene integrin subunit alpha 3 S homeolog Neighboring gene frizzled class receptor 2 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xenopus Distal-less related homeobox genes are expressed in the developing forebrain and are induced by planar signals. Papalopulu N, et al. Development, 1993 Mar. PMID 8100768
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein DLL-2-like
    Names
    distal-less homeo box 3, putative transcription factor DLL2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      4539235..4547354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018238050.2 → XP_018093539.1  homeobox protein DLL-2-like

      UniProtKB/TrEMBL
      A0A1L8EL03, A0A974H096, Q1JQ72
      Related
      ENSXLAP00005096123.1, ENSXLAT00005097890.1
    Nucleotide Protein Strain
    Heading Accession and Version

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