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    gss.L glutathione synthetase L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 394329, updated on 27-Dec-2024

    Summary

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    Official Symbol
    gss.L
    Official Full Name
    glutathione synthetase L homeolog
    Primary source
    Xenbase:XB-GENE-6254454
    Locus tag
    XELAEV_18043940mg
    See related
    EnsemblRapid:ENSXLAG00005030973 AllianceGenome:Xenbase:XB-GENE-6254454
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    gss; gssls-a
    Summary
    Predicted to enable anion binding activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to act upstream of or within glutathione biosynthetic process. Is expressed in liver and biliary system and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See gss.L in Genome Data Viewer
    Location:
    chromosome: 9_10L
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (43590997..43606714, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (33274056..33289909, complement)

    Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121398204 Neighboring gene acyl-CoA synthetase short chain family member 2, gene 1 L homeolog Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta L homeolog Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of the large subunit of glutathione synthetase from Xenopus laevis embryos. Habenicht A, et al. Biochim Biophys Acta, 1993 Sep 23. PMID 7916638
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione synthetase
    Names
    GSH synthetase
    GSH-S
    glutathione synthase
    glutathione synthetase, large subunit
    NP_001081013.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001087544.1 → NP_001081013.1  glutathione synthetase

      See identical proteins and their annotated locations for NP_001081013.1

      Status: PROVISIONAL

      Source sequence(s)
      X69662
      UniProtKB/Swiss-Prot
      P35668
      UniProtKB/TrEMBL
      A0A974BXN4, Q6DCN4
      Related
      ENSXLAP00005093210.1, ENSXLAT00005094893.1
      Conserved Domains (1) summary
      cd00228
      Location:6 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      43590997..43606714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35668.1 GenPept UniProtKB/Swiss-Prot:P35668

    Gene LinkOut

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