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    ROS1 ROS proto-oncogene 1, receptor tyrosine kinase [ Gallus gallus (chicken) ]

    Gene ID: 396192, updated on 3-Dec-2024

    Summary

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    Symbol
    ROS1provided by CGNC
    Full Name
    ROS proto-oncogene 1, receptor tyrosine kinaseprovided by CGNC
    Primary source
    CGNC:11070
    See related
    Ensembl:ENSGALG00010012360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ROS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (63161245..63244863)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (63020318..63103944)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene golgi associated PDZ and coiled-coil motif containing Neighboring gene uncharacterized LOC124417811 Neighboring gene discoidin, CUB and LCCL domain containing 1 Neighboring gene uncharacterized LOC101749120 Neighboring gene vestigial like family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chicken proto-oncogene c-ros cDNA clones: identification of a c-ros RNA transcript and deduction of the amino acid sequence of the carboxyl terminus of the c-ros product. Podell SB, et al. Oncogene, 1987. PMID 3325887
    2. Proto-oncogene c-ros codes for a molecule with structural features common to those of growth factor receptors and displays tissue specific and developmentally regulated expression. Neckameyer WS, et al. Mol Cell Biol, 1986 May. PMID 3023892, Free PMC Article
    3. The proto-oncogene c-ros codes for a transmembrane tyrosine protein kinase sharing sequence and structural homology with sevenless protein of Drosophila melanogaster. Chen JM, et al. Oncogene, 1991 Feb. PMID 1900358
    4. Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule. Matsushime H, et al. Mol Cell Biol, 1986 Aug. PMID 3023956, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proto-oncogene tyrosine-protein kinase ROS
    Names
    ROS proto-oncogene 1 , receptor tyrosine kinase
    c-Ros receptor tyrosine kinase
    c-ros oncogene 1 , receptor tyrosine kinase
    c-ros-1
    proto-oncogene c-Ros
    proto-oncogene c-Ros-1
    receptor tyrosine kinase c-ros oncogene 1
    v-ros UR2 sarcoma virus oncogene homolog 1
    NP_990588.2
    XP_046769180.1
    XP_046769181.1
    XP_046794483.1
    XP_046794484.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205257.4 → NP_990588.2  proto-oncogene tyrosine-protein kinase ROS precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000065
      UniProtKB/Swiss-Prot
      P08941
      UniProtKB/TrEMBL
      F1NQL9
      Related
      ENSGALP00010017222.1, ENSGALT00010029602.1
      Conserved Domains (2) summary
      cd00063
      Location:572 → 668
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05044
      Location:1965 → 2234
      PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      63161245..63244863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046938527.1 → XP_046794483.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

      UniProtKB/Swiss-Prot
      P08941
      UniProtKB/TrEMBL
      F1NQL9

    2. XM_046938528.1 → XP_046794484.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

      UniProtKB/Swiss-Prot
      P08941
      UniProtKB/TrEMBL
      F1NQL9

    RNA

    1. XR_005858072.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      63020318..63103944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046913224.1 → XP_046769180.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

      UniProtKB/Swiss-Prot
      P08941
      UniProtKB/TrEMBL
      F1NQL9

    2. XM_046913225.1 → XP_046769181.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

      UniProtKB/Swiss-Prot
      P08941
      UniProtKB/TrEMBL
      F1NQL9

    RNA

    1. XR_006933914.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08941.3 GenPept UniProtKB/Swiss-Prot:P08941

    Gene LinkOut

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