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    sox17a.L SRY-box 17 alpha L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 397966, updated on 20-Nov-2024

    Summary

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    Official Symbol
    sox17a.L
    Official Full Name
    SRY-box 17 alpha L homeolog
    Primary source
    Xenbase:XB-GENE-865067
    Locus tag
    XELAEV_18032020mg
    See related
    EnsemblRapid:ENSXLAG00005015583 AllianceGenome:Xenbase:XB-GENE-865067
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    sox17; sox17a; xsox17; sox17.L; sox17a1; xsox17a; sox17a-a; Sox17alpha; sox17-alpha; tSox17alpha; xsox17-alpha
    Summary
    Enables beta-catenin binding activity. Acts upstream of or within several processes, including digestive tract development; negative regulation of canonical Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in cardiovascular system; ectoderm; endoderm; and liver and biliary system. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sox17a.L in Genome Data Viewer
    Location:
    chromosome: 6L
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (122899051..122901477)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (115774101..115776634)

    Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene protein ENDO16-like Neighboring gene mitochondrial ribosomal protein L15 L homeolog Neighboring gene SRY (sex determining region Y)-box 17 beta, gene 1 L homeolog Neighboring gene RP1, axonemal microtubule associated L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. VegT activation of Sox17 at the midblastula transition alters the response to nodal signals in the vegetal endoderm domain. Engleka MJ, et al. Dev Biol, 2001 Sep 1. PMID 11518513
    2. Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis. Xanthos JB, et al. Development, 2001 Jan. PMID 11124113
    3. Cephalic hedgehog expression is regulated directly by Sox17 in endoderm development of Xenopus laevis. Yagi Y, et al. Cytotechnology, 2008 Jun. PMID 19003160, Free PMC Article
    4. Regulation of the Xenopus Xsox17alpha(1) promoter by co-operating VegT and Sox17 sites. Howard L, et al. Dev Biol, 2007 Oct 15. PMID 17719026, Free PMC Article
    5. VegT induces endoderm by a self-limiting mechanism and by changing the competence of cells to respond to TGF-beta signals. Clements D, et al. Dev Biol, 2003 Jun 15. PMID 12798301

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. two regions co-operate in regulating the early endodermal expression of the Xsox17alpha(1) gene
      Title: Regulation of the Xenopus Xsox17alpha(1) promoter by co-operating VegT and Sox17 sites.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC131036

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gastrulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within midgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Sox-17-alpha-A
    Names
    SRY (sex determining region Y)-box 17 alpha
    SRY-box 17 L homeolog
    sox17 alpha
    xSox17alpha2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088162.1 → NP_001081631.1  transcription factor Sox-17-alpha-A

      See identical proteins and their annotated locations for NP_001081631.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ001730
      UniProtKB/Swiss-Prot
      O42600, Q3KQ35, Q90ZI0
      Related
      ENSXLAP00005045775.1, ENSXLAT00005046873.1
      Conserved Domains (2) summary
      cd01388
      Location:60 → 131
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam12067
      Location:187 → 378
      Sox_C_TAD; Sox C-terminal transactivation domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      122899051..122901477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KQ35.1 GenPept UniProtKB/Swiss-Prot:Q3KQ35

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials