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    elmo2.S engulfment and cell motility 2 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398953, updated on 4-Jan-2025

    Summary

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    Official Symbol
    elmo2.S
    Official Full Name
    engulfment and cell motility 2 S homeolog
    Primary source
    Xenbase:XB-GENE-986990
    Locus tag
    XELAEV_18046556mg
    See related
    EnsemblRapid:ENSXLAG00005028728 AllianceGenome:Xenbase:XB-GENE-986990
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    ced12; ced-12; elmo-2
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to act upstream of or within apoptotic process and phagocytosis. Orthologous to human ELMO2 (engulfment and cell motility 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See elmo2.S in Genome Data Viewer
    Location:
    chromosome: 9_10S
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (32636424..32669465)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (27148577..27181704)

    Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene cyclin D-type binding-protein 1 S homeolog Neighboring gene small nuclear ribonucleoprotein polypeptides B and B1 S homeolog Neighboring gene solute carrier family 35 (GDP-fucose transporter), member C2 S homeolog Neighboring gene waprin-Rha1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. Epting D, et al. Development, 2015 Jan 1. PMID 25516973
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC68475

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    engulfment and cell motility 2 S homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001090018.1 → NP_001083487.1  engulfment and cell motility 2 S homeolog

      See identical proteins and their annotated locations for NP_001083487.1

      Status: PROVISIONAL

      Source sequence(s)
      BC060396
      UniProtKB/TrEMBL
      A0A974BTK4, Q6PAA3
      Related
      ENSXLAP00005085807.1, ENSXLAT00005087469.1
      Conserved Domains (3) summary
      cd13359
      Location:551 → 680
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:309 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 283
      DUF3361; Domain of unknown function (DUF3361)

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      32636424..32669465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018237380.2 → XP_018092869.1  engulfment and cell motility 2 S homeolog isoform X2

      UniProtKB/TrEMBL
      A0A8J0U0H8
      Related
      ENSXLAP00005085704.1, ENSXLAT00005087366.1

    2. XM_018237378.2 → XP_018092867.1  engulfment and cell motility 2 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A974BTK4, Q6PAA3

    3. XM_018237377.2 → XP_018092866.1  engulfment and cell motility 2 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A974BTK4, Q6PAA3

    4. XM_018237379.2 → XP_018092868.1  engulfment and cell motility 2 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A974BTK4, Q6PAA3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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