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    Dysb Dysbindin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40052, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dysbprovided by FlyBase
    Official Full Name
    Dysbindinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036819
    Locus tag
    Dmel_CG6856
    See related
    AllianceGenome:FB:FBgn0036819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6856; Ddysb; Dmel\CG6856; dysb; dysbindin; NP_649064
    Summary
    Involved in several processes, including eye pigment granule organization; learning or memory; and modulation of chemical synaptic transmission. Located in neuromuscular junction of somatic muscle and synaptic vesicle. Part of BLOC-1 complex. Is expressed in adult central brain; adult optic lobe glial cell; embryonic/larval salivary gland; and organism. Used to study metal metabolism disorder and schizophrenia. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 7 and schizophrenia. Orthologous to human DTNBP1 (dystrobrevin binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Dysb in Genome Data Viewer
    Location:
    75E2-75E2; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18867771..18869219)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18860871..18862319)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45912 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutaredoxin 1 Neighboring gene Rad9 Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DISC1 causes associative memory and neurodevelopmental defects in fruit flies. Furukubo-Tokunaga K, et al. Mol Psychiatry, 2016 Sep. PMID 26976042, Free PMC Article
    2. Visualization of DISC1-Dysbindin interaction in glutamatergic synaptic termini in fruit flies. Furukubo-Tokunaga K, et al. Mol Psychiatry, 2016 Sep. PMID 27545194
    3. The β-alanyl-monoamine synthase ebony is regulated by schizophrenia susceptibility gene dysbindin in Drosophila. Lu B, et al. Sci China Life Sci, 2014 Jan. PMID 24399135
    4. The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms. Hidalgo S, et al. Neurochem Int, 2020 Sep. PMID 32416114
    5. The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression. Baccino-Calace M, et al. Elife, 2022 Jul 7. PMID 35796533, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysbindin levels regulate the access to EGTA-sensitive vesicles at the neuromuscular junction.
      Title: Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles.
    2. Results indicate that perturbations downstream of DTNBP1, confer susceptibility to copper, a metal that in excess is a neurotoxin and whose depletion constitutes a micronutrient deficiency.
      Title: Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor.
    3. Loss-of-function alleles of dysbindin or Blos1 impaired neurotransmitter release and synaptic function and plasticity.
      Title: Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity.
    4. optimal binding ratio between Dysb and Ebony might contribute to such non-linear effects. Thus, Ddysb-dependent regulation of Ebony could be one of the mechanisms that mediate dopamine signal
      Title: The β-alanyl-monoamine synthase ebony is regulated by schizophrenia susceptibility gene dysbindin in Drosophila.
    5. Ddysb regulates glutamatergic transmission through its neuronal function and regulates dopamine metabolism by regulating Ebony expression in glial cells
      Title: Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila.
    6. study found that dysbindin (CG6856) is required presynaptically for the retrograde, homeostatic modulation of neurotransmission, and functions in a dose-dependent manner downstream or independently of calcium influx
      Title: The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye pigment granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating behavior, sex discrimination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of dopamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of dopamine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synapse organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle recycling via endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BLOC-1 complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of BLOC-1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuromuscular junction of somatic muscle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dysbindin
    Names
    CG6856-PA
    CG6856-PB
    Dysb-PA
    Dysb-PB
    dysbindin ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18867771..18869219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140807.4 → NP_649064.1  dysbindin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649064.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVT5
      UniProtKB/TrEMBL
      M9PI95
      Related
      FBpp0074829
      Conserved Domains (1) summary
      pfam07851
      Location:94 → 189
      TMPIT; TMPIT-like protein

    2. NM_001275094.1 → NP_001262023.1  dysbindin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262023.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVT5
      UniProtKB/TrEMBL
      M9PI95
      Conserved Domains (1) summary
      pfam07851
      Location:94 → 189
      TMPIT; TMPIT-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI95 M9PI95
    Q9VVT5.1 Q9VVT5

    Gene LinkOut

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