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    Edg78E Ecdysone-dependent gene 78E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40354, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Edg78Eprovided by FlyBase
    Official Full Name
    Ecdysone-dependent gene 78Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000551
    Locus tag
    Dmel_CG7673
    See related
    AllianceGenome:FB:FBgn0000551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7673; DmelEdg78E; Dmel\CG7673; DMLCP78; EDG-78; Edg78; EDG78; Edg78e; EDG78E
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in epidermis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Edg78E in Genome Data Viewer
    Location:
    78C6-78C6; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21296763..21297803, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21289863..21290903, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 78Ca Neighboring gene Cuticular protein 78Cb Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 78Cc

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BetaFTZ-F1 dependent and independent activation of Edg78E, a pupal cuticle gene, during the early metamorphic period in Drosophila melanogaster. Kawasaki H, et al. Dev Growth Differ, 2002 Oct. PMID 12392575
    2. 20-Hydroxyecdysone is required for, and negatively regulates, transcription of Drosophila pupal cuticle protein genes. Apple RT, et al. Dev Biol, 1991 Aug. PMID 1713868
    3. Evolution of the Drosophila broad locus: the Manduca sexta broad Z4 isoform has biological activity in Drosophila. Bayer C, et al. Dev Genes Evol, 2003 Oct. PMID 13680224
    4. Prepupal differentiation of Drosophila imaginal discs: identification of four genes whose transcripts accumulate in response to a pulse of 20-hydroxyecdysone. Fechtel K, et al. Genetics, 1988 Oct. PMID 2461886, Free PMC Article
    5. Prepupal differentiation in Drosophila: distinct cell types elaborate a shared structure, the pupal cuticle, but accumulate transcripts in unique patterns. Fechtel K, et al. Development, 1989 Aug. PMID 2562660

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables structural constituent of pupal chitin-based cuticle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ecdysone-dependent gene 78E
    Names
    CG7673-PA
    CG7673-PB
    Edg78E-PA
    Edg78E-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21296763..21297803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079474.3 → NP_524198.1  Ecdysone-dependent gene 78E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524198.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27779, Q9VP54
      UniProtKB/TrEMBL
      D4G7H0, X2JGZ5
      Related
      FBpp0078062
      Conserved Domains (1) summary
      pfam00379
      Location:39 → 85
      Chitin_bind_4; Insect cuticle protein

    2. NM_001300211.1 → NP_001287140.1  Ecdysone-dependent gene 78E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287140.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27779, Q9VP54
      UniProtKB/TrEMBL
      D4G7H0, X2JGZ5
      Conserved Domains (1) summary
      pfam00379
      Location:39 → 85
      Chitin_bind_4; Insect cuticle protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27779.1 P27779
    X2JGZ5 X2JGZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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