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    COX8 Cytochrome c oxidase subunit 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40390, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX8provided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0263911
    Locus tag
    Dmel_CG7181
    See related
    AllianceGenome:FB:FBgn0263911
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0554/18; anon-WO0118547.331; BcDNA:GH15688; CcO VIIc; CG7181; CoVIII; Dmel\CG7181; l(3)S055418; VIII
    Summary
    Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See COX8 in Genome Data Viewer
    Location:
    78D5-78D5; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21538859..21539447, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21531959..21532547, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pickpocket 5 Neighboring gene Regulatory particle non-ATPase 10 Neighboring gene Vacuolar H[+] ATPase M9.7 subunit b Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vectors for Genetically-Encoded Tags for Electron Microscopy Contrast in Drosophila. Tsui MM, et al. Biol Proced Online, 2016. PMID 26839516, Free PMC Article
    2. Deletion of proteasomal subunit S5a/Rpn10/p54 causes lethality, multiple mitotic defects and overexpression of proteasomal genes in Drosophila melanogaster. Szlanka T, et al. J Cell Sci, 2003 Mar 15. PMID 12584246
    3. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Klichko V, et al. Biochem J, 2014 Apr 1. PMID 24444354
    4. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Ren JC, et al. Biochem Biophys Res Commun, 2010 Oct 8. PMID 20833144, Free PMC Article
    5. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Porcelli D, et al. Mitochondrion, 2010 Aug. PMID 20388558

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 8
    Names
    CG7181-PA
    CG7181-PB
    COX8-PA
    COX8-PB
    cytochrome c oxidase subunit VIII
    lethal (3) S055418
    subunit VIII

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21538859..21539447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275240.1 → NP_001262169.1  cytochrome c oxidase subunit 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP19
      Conserved Domains (1) summary
      pfam02285
      Location:26 → 65
      COX8; Cytochrome oxidase c subunit VIII

    2. NM_141071.2 → NP_649328.1  cytochrome c oxidase subunit 8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP19
      Related
      FBpp0078037
      Conserved Domains (1) summary
      pfam02285
      Location:26 → 65
      COX8; Cytochrome oxidase c subunit VIII
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP19 Q9VP19

    Gene LinkOut

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