5-HT2A 5-hydroxytryptamine (serotonin) receptor 2A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: 5-HT2Aprovided by FlyBase
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 2Aprovided by FlyBase
Primary source: FLYBASE:FBgn0087012
Locus tag: Dmel_CG1056
See related: AllianceGenome:FB:FBgn0087012
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5-HT; 5-HT-2a; 5-HT2; 5-ht2Dro; 5-HT2Dro; 5-HT[2]Dro; 5-HT[[2Dro]]; 5-HT[[2]]; 5-HT[[2]]Dro; 5HT-dro[[1]]; 5HT-R82A; 5HT2; 5HT2-Dro; 5HT2a; 5HT2A; 5HT2Dro; 5HT[[2Dro]]; CG1056; d5-HT2; d5-HT2A; Dm5-HT2A; Dm5-HT[[2A]]; Dm5HT2; Dmel\CG1056; l(3)82CDb
Summary: Enables G protein-coupled serotonin receptor activity. Involved in germ-band extension; positive regulation of feeding behavior; and serotonin receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including adult protocerebrum; dorsal ectoderm; dorsal ectoderm anlage; ganglia; and large field neurons. Used to study generalized anxiety disorder. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 82C3-82C4; 3-47.1 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4612870..4633304)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (438592..459026)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice.
Title: Drosophila serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice.
5-HT2 A receptor has been widely investigated for its association with schizophrenia.
Title: An association study of dopaminergic (DRD2) and serotoninergic (5-HT2) gene polymorphism and schizophrenia in a North Indian population.
Our results do not support the notion that low cholesterol levels universally lead to higher impulsivity, but it was found that high total and LDL cholesterol levels moderate the effect of the HTR2A gene promoter polymorphism.
Title: Effect of a human serotonin 5-HT(2A) receptor gene polymorphism on impulsivity: Dependence on cholesterol levels.
The A allele of the 1438G/A gene polymorphism in 5-HTR2A is predominantly distributed in males and increased the obstructive sleep apnea syndrome risk significantly.
Title: A systematic review and meta-analysis of the association between serotonergic gene polymorphisms and obstructive sleep apnea syndrome.
5-HT2a receptor is involved in the action of 5-HT on the heart rate in the larval stage.
Title: Pharmacological and genetic identification of serotonin receptor subtypes on Drosophila larval heart and aorta.
study describes the influence of different 5-HT receptor subtypes on aggressive behaviors; activation of 5-HT(2) receptors with (R)-DOI appears to decrease overall aggression; 5-HT(2) receptor manipulation primarily alters lunging and boxing
Title: Serotonin 5-HT(2) and 5-HT(1A)-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster.
5-HT(2Dro) (C1644)is a point mutation that generates a gain of serotonin affinity for the receptor and affects germband extension.
Title: Gain of affinity point mutation in the serotonin receptor gene 5-HT2Dro accelerates germband extension movements during Drosophila gastrulation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 4616733-4617016 mobile_element_type = transposon:INE-1{}4443
Loc: 4620470-4620579 mobile_element_type = transposon:INE-1{}4457
Loc: 4626264-4626320 mobile_element_type = transposon:INE-1{}4461
Loc: 4631408-4631673 mobile_element_type = transposon:INE-1{}4465

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled serotonin receptor activity	TAS Traceable Author Statement more info	PubMed
enables Gq/11-coupled serotonin receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in germ-band extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in serotonin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine (serotonin) receptor 2A

Names: 5-HT2A-PA; 5-HT2A-PB; 5-HT2A-PD; 5-HT2A-PF; 5-HT2A-PH; 5-HT[[2]]Dro receptor; CG1056-PA; CG1056-PB; CG1056-PD; CG1056-PF; CG1056-PH; lethal (3) 82CDb; serotonin receptor 2; serotonin receptor 2a

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

4612870..4633304

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079499.4 → NP_524223.2 5-hydroxytryptamine (serotonin) receptor 2A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524223.2

Status: REVIEWED

UniProtKB/TrEMBL

Q24511, Q9VN38

Related

FBpp0078494

Conserved Domains (2) summary

pfam00001
Location:302 → 477

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:299 → 428

7tm_4; Olfactory receptor
NM_169011.3 → NP_730859.1 5-hydroxytryptamine (serotonin) receptor 2A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730859.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24511, Q8IPN2

Related

FBpp0078495

Conserved Domains (2) summary

pfam00001
Location:302 → 477

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:299 → 428

7tm_4; Olfactory receptor
NM_001104214.3 → NP_001097684.2 5-hydroxytryptamine (serotonin) receptor 2A, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097684.2

Status: REVIEWED

UniProtKB/TrEMBL

A8JQT4, Q24511

Conserved Domains (2) summary

pfam00001
Location:302 → 477

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:299 → 428

7tm_4; Olfactory receptor
NM_001170034.2 → NP_001163505.1 5-hydroxytryptamine (serotonin) receptor 2A, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163505.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6AWQ4

Conserved Domains (2) summary

pfam00001
Location:302 → 477

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:299 → 428

7tm_4; Olfactory receptor
NM_001170035.2 → NP_001163506.2 5-hydroxytryptamine (serotonin) receptor 2A, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163506.2

Status: REVIEWED

UniProtKB/TrEMBL

E1JJ46, Q24511

Conserved Domains (2) summary

pfam00001
Location:302 → 477

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:299 → 428

7tm_4; Olfactory receptor