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    CNGA2 cyclic nucleotide gated channel subunit alpha 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 407172, updated on 29-Jan-2025

    Summary

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    Official Symbol
    CNGA2provided by VGNC
    Official Full Name
    cyclic nucleotide gated channel subunit alpha 2provided by VGNC
    Primary source
    VGNC:VGNC:27498
    See related
    BGD:BT17796; Ensembl:ENSBTAG00000020725
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CNGa3; OCNC1
    Orthologs
    human mouse all
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    Genomic context

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    See CNGA2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (34207163..34223860)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene proline rich and Gla domain 3 Neighboring gene fetal and adult testis expressed 1 Neighboring gene melanoma-associated antigen 10 Neighboring gene microRNA mir-3431 Neighboring gene gamma-aminobutyric acid type A receptor subunit epsilon

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Primary structure of cAMP-gated channel from bovine olfactory epithelium. Ludwig J, et al. FEBS Lett, 1990 Sep 17. PMID 1699793
    2. Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels. Shen B, et al. J Mol Cell Cardiol, 2008 Sep. PMID 18621055
    3. CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells. Cheng KT, et al. Arterioscler Thromb Vasc Biol, 2008 May. PMID 18292397
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mediates epinephrine-induced endothelial calcium influx and subsequent vascular dilation.
      Title: Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels.
    2. CNGA2 channels play a key role in adenosine-induced endothelial Ca(2+) influx and vasorelaxation
      Title: CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables intracellularly cAMP-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables intracellularly cGMP-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic nucleotide-gated channel alpha-2
    Names
    CNCalpha3
    CNG channel alpha-2
    CNG-2
    CNG2
    cAMP-gated channel
    cyclic nucleotide gated channel alpha 2
    cyclic nucleotide-gated cation channel 2
    cyclic nucleotide-gated channel alpha 3
    cyclic nucleotide-gated olfactory channel
    olfactory cyclic nucleotide-gated channel subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001139.2 → NP_001001139.1  cyclic nucleotide-gated channel alpha-2

      See identical proteins and their annotated locations for NP_001001139.1

      Status: PROVISIONAL

      Source sequence(s)
      X55010
      UniProtKB/Swiss-Prot
      Q03041
      Related
      ENSBTAP00070048010.1, ENSBTAT00070078921.1
      Conserved Domains (5) summary
      COG0664
      Location:448 → 624
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:454 → 570
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:164 → 382
      Ion_trans; Ion transport protein
      pfam16526
      Location:570 → 639
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
      cl18962
      Location:415 → 468
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      34207163..34223860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03041.1 GenPept UniProtKB/Swiss-Prot:Q03041

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