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    BSP1 binder of sperm 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 407187, updated on 1-Jan-2025

    Summary

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    Gene symbol
    BSP1
    Gene description
    binder of sperm 1
    See related
    Ensembl:ENSBTAG00000023434
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PDC109; PDC-109; SVSP109
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    Genomic context

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    See BSP1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (51618421..51622953)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene binder of sperm 5 Neighboring gene seminal plasma protein A3 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene transfer RNA alanine (anticodon AGC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Conformational dynamics and ligand binding in the multi-domain protein PDC109. Kim HJ, et al. PLoS One, 2010 Feb 18. PMID 20174627, Free PMC Article
    2. Refined solution structure and ligand-binding properties of PDC-109 domain b. A collagen-binding type II domain. Constantine KL, et al. J Mol Biol, 1992 Jan 5. PMID 1731074
    3. Characterization of the gene for the bovine seminal vesicle secretory protein SVSP109. Bräuer C, et al. Biochim Biophys Acta, 1991 Oct 8. PMID 1932121
    4. Sequence-specific 1H NMR assignments and structural characterization of bovine seminal fluid protein PDC-109 domain b. Constantine KL, et al. Biochemistry, 1991 Feb 12. PMID 1993183
    5. Cloning and sequence analysis of a cDNA from seminal vesicle tissue encoding the precursor of the major protein of bull semen. Kemme M, et al. DNA, 1988 Nov. PMID 3229283

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conserved core tryptophans of FnII domains are crucial for the membranolytic and chaperone-like activities of bovine seminal plasma protein PDC-109.
      Title: Conserved core tryptophans of FnII domains are crucial for the membranolytic and chaperone-like activities of bovine seminal plasma protein PDC-109.
    2. Glycosylation decreases the membranolytic activity of PDC-109 but increases its chaperone-like activities.
      Title: Glycosylation differentially modulates membranolytic and chaperone-like activities of PDC-109, the major protein of bovine seminal plasma.
    3. PDC-109 binds to choline phospholipids of the sperm plasma membrane and induces an efflux of cholesterol and choline phospholipids, which is crucial for sperm capacitation. PDC-109 also exhibits chaperone-like activity and protects target proteins against various kinds of stress. Spermine and spermidine, present in high concentration in the seminal plasma, increase the ability of PDC-109 to perturb membrane structure.
      Title: Spermine and spermidine act as chemical chaperones and enhance chaperone-like and membranolytic activities of major bovine seminal plasma protein, PDC-109.
    4. This is the first report showing that more than two forms of BSP1 are found in the seminal plasma of Nelore adult bulls and not all animals have a similar abundance of each BSP1 form.
      Title: Differential abundances of four forms of Binder of SPerm 1 in the seminal plasma of Bos taurus indicus bulls with different patterns of semen freezability.
    5. abundant in bull sperm, more in low fertility group than in high fertility group
      Title: Profiling of sperm proteins and association of sperm PDC-109 with bull fertility.
    6. Data indicate the temperature dependence of the thermodynamics in the binding of PDC-109 to O-lauroylcholine and O-myristoylcholine.
      Title: Biophysical characterization of the interaction of O-acylcholines with the major bovine seminal plasma protein, PDC-109.
    7. Data suggest that binding of BSP1, BSP3, and BSP5 is increased on surface of bull sperm following cryopreservation; binder of sperm proteins appear to play roles in formation of oviductal sperm storage reservoir and in sperm capacitation.
      Title: Cryopreservation increases coating of bull sperm by seminal plasma binder of sperm proteins BSP1, BSP3, and BSP5.
    8. analysis of chemical and physical requirements for lipid extraction by bovine binder of sperm BSP1
      Title: Chemical and physical requirements for lipid extraction by bovine binder of sperm BSP1.
    9. The presence of BSP1 over the acrosomal region characterises spermatozoa sensitive to cryopreservation and ELSPBP1 characterises spermatozoa that are already dead at ejaculation.
      Title: Binder of sperm 1 and epididymal sperm binding protein 1 are associated with different bull sperm subpopulations.
    10. Large oligomeric structures are formed upon binding of PDC-109 to heparin, indicating an increase in the local density of the protein, which may be relevant to the ability of heparin to potentiate PDC-109 induced sperm capacitation.
      Title: Biophysical investigations on the interaction of the major bovine seminal plasma protein, PDC-109, with heparin.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sperm capacitation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    seminal plasma protein PDC-109
    Names
    BSP-A1 and BSP-A2
    seminal vesicle secretory protein 109

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001145.1 → NP_001001145.1  seminal plasma protein PDC-109 precursor

      Status: PROVISIONAL

      Source sequence(s)
      M22244
      UniProtKB/Swiss-Prot
      P02784
      UniProtKB/TrEMBL
      A0AAF6ZKY4
      Related
      ENSBTAP00000051819.3, ENSBTAT00000055955.4
      Conserved Domains (1) summary
      smart00059
      Location:87 → 134
      FN2; Fibronectin type 2 domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      51618421..51622953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02784.2 GenPept UniProtKB/Swiss-Prot:P02784

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials