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    wtrw water witch [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40931, updated on 17-Dec-2024

    Summary

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    Official Symbol
    wtrwprovided by FlyBase
    Official Full Name
    water witchprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260005
    Locus tag
    Dmel_CG31284
    See related
    AllianceGenome:FB:FBgn0260005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153412_at; CG10409; CG17817; CG31284; CT29234; Dmel\CG31284; dTRPA3; trpA3; Wtrw; ww
    Summary
    Contributes to calcium channel activity. Involved in calcium ion transmembrane transport; response to humidity; and sensory perception of sound. Part of calcium channel complex. Is expressed in Johnston organ; embryonic epipharynx; embryonic foregut; organism subdivision; and yolk nucleus. Orthologous to human ANKRD61 (ankyrin repeat domain 61). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wtrw in Genome Data Viewer
    Location:
    84E4-84E4; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7891331..7901147)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3717053..3726869)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46127 Neighboring gene Arginyl-tRNA synthetase, mitochondrial Neighboring gene mitochondrial ribosomal protein S9 Neighboring gene ER membrane protein complex subunit 1 Neighboring gene TBP-associated factor 7 Neighboring gene Phosphoribosylamidotransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amines, Astrocytes, and Arousal. Bazargani N, et al. Neuron, 2017 Apr 19. PMID 28426956
    2. A novel assay reveals hygrotactic behavior in Drosophila. Ji F, et al. PLoS One, 2015. PMID 25738801, Free PMC Article
    3. TRPV channel nanchung and TRPA channel water witch form insecticide-activated complexes. Kandasamy R, et al. Insect Biochem Mol Biol, 2022 Oct. PMID 36087889
    4. Opposite thermosensor in fruitfly and mouse. Viswanath V, et al. Nature, 2003 Jun 19. PMID 12815418
    5. A doublecortin containing microtubule-associated protein is implicated in mechanotransduction in Drosophila sensory cilia. Bechstedt S, et al. Nat Commun, 2010 Apr 12. PMID 20975667, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to calcium channel activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables monoatomic cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in monoatomic cation transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to humidity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of calcium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cation channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    water witch
    Names
    CG31284-PA
    CG31284-PB
    CG31284-PC
    CG31284-PD
    waterwitch
    wtrw-PA
    wtrw-PB
    wtrw-PC
    wtrw-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7891331..7901147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169201.2 → NP_731194.1  water witch, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731194.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5X0K8, Q6NQV8, Q9VHY7
      Related
      FBpp0081251
      Conserved Domains (4) summary
      cd00204
      Location:323 → 443
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:613 → 812
      Ion_trans; Ion transport protein
      pfam12796
      Location:325 → 420
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:323 → 351
      ANK; ANK repeat [structural motif]

    2. NM_206459.2 → NP_996181.1  water witch, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996181.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5X0K8, Q6NQV8, Q9VHY7
      Conserved Domains (4) summary
      cd00204
      Location:323 → 443
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:613 → 812
      Ion_trans; Ion transport protein
      pfam12796
      Location:325 → 420
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:323 → 351
      ANK; ANK repeat [structural motif]

    3. NM_169200.2 → NP_731193.1  water witch, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731193.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5X0K8, Q6NQV8, Q9VHY7
      Related
      FBpp0081250
      Conserved Domains (4) summary
      cd00204
      Location:323 → 443
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:613 → 812
      Ion_trans; Ion transport protein
      pfam12796
      Location:325 → 420
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:323 → 351
      ANK; ANK repeat [structural motif]

    4. NM_001300285.1 → NP_001287214.1  water witch, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGT2, B5X0K8, Q6NQV8
      Conserved Domains (4) summary
      cd00204
      Location:306 → 426
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:596 → 795
      Ion_trans; Ion transport protein
      pfam12796
      Location:308 → 403
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:306 → 334
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGT2 A0A0B4LGT2
    Q6NQV8 Q6NQV8
    Q9VHY7 Q9VHY7

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