CG5961 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG5961provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0038056
Locus tag: Dmel_CG5961
See related: AllianceGenome:FB:FBgn0038056
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG5961; FBXO9
Summary: Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval midgut; larval somatic muscle cell; and sensory nervous system primordium. Used to study Parkinson's disease. Orthologous to human FBXO9 (F-box protein 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 87B11-87B11; 3-52 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12458421..12460294, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8284143..8286016, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterizing the putative Drosophila melanogaster homologue of this gene, CG5961, enables modeling and analysis of the consequence of targeted alteration of gene function and the effects on the overall health of the organism.Our results suggest that CG5961 activity is necessary for the proper formation of neuronal tissue and that targeted alteration of gene expression in dopaminergic neurons leads to a reduced lifespan.
Title: Altered expression of CG5961, a putative Drosophila melanogaster homologue of FBXO9, provides a new model of Parkinson disease.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISM Inferred from Sequence Model more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of SCF ubiquitin ligase complex	ISM Inferred from Sequence Model more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG5961-PA; CG5961-PB; CG5961-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

12458421..12460294 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202282.1 → NP_001189211.1 uncharacterized protein Dmel_CG5961, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189211.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VG61

Conserved Domains (2) summary

pfam12937
Location:179 → 225

F-box-like; F-box-like

cl00299
Location:74 → 131

MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
NM_001300378.1 → NP_001287307.1 uncharacterized protein Dmel_CG5961, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287307.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VG61

Conserved Domains (2) summary

pfam12937
Location:179 → 225

F-box-like; F-box-like

cl00299
Location:74 → 131

MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
NM_141949.4 → NP_650206.1 uncharacterized protein Dmel_CG5961, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650206.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VG61

Related

FBpp0082149

Conserved Domains (2) summary

pfam12937
Location:179 → 225

F-box-like; F-box-like

cl00299
Location:74 → 131

MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...