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    CG45105 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41932, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG45105provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266566
    Locus tag
    Dmel_CG45105
    See related
    AllianceGenome:FB:FBgn0266566
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14878; CG31291; CG34275; CG5552; Dmel\CG45105
    Old locus tag
    Dmel_CG31291; Dmel_CG34275
    Summary
    Predicted to be involved in several processes, including microtubule organizing center organization; neuron migration; and tube formation. Predicted to be active in centriole and centrosome. Is expressed in several structures, including antennal primordium; dorsal sensory complex primordium; embryonic head sensory system; sensory nervous system primordium; and ventral sensory complex anlage. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 16 and Senior-Loken syndrome. Orthologous to human SDCCAG8 (SHH signaling and ciliogenesis regulator SDCCAG8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG45105 in Genome Data Viewer
    Location:
    89A8-89A8; 3-58 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15910372..15918007, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11736094..11743729, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Endoribonuclease U-specific Neighboring gene antisense RNA:CR46470 Neighboring gene long non-coding RNA:CR46028 Neighboring gene F-box and leucine-rich repeat protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila auditory organ genes and genetic hearing defects. Senthilan PR, et al. Cell, 2012 Aug 31. PMID 22939627
    2. Spitz from the retina regulates genes transcribed in the second mitotic wave, peripodial epithelium, glia and plasmatocytes of the Drosophila eye imaginal disc. Firth LC, et al. Dev Biol, 2007 Jul 15. PMID 17553483, Free PMC Article
    3. A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi. Fisher WW, et al. Genetics, 2023 Apr 6. PMID 36652461, Free PMC Article
    4. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N, et al. Development, 2014 Oct. PMID 25294943, Free PMC Article
    5. Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits. Durham MF, et al. Nat Commun, 2014 Jul 8. PMID 25000897

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in centrosome cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule organizing center organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tube formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG45105-PB
    CG45105-PC
    CG45105-PD
    CG45105-PE
    CG45105-PF
    CG45105-PG
    CG45105-PH
    CG45105-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15910372..15918007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169682.2 → NP_732085.1  uncharacterized protein Dmel_CG45105, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732085.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF13
      Related
      FBpp0311012
      Conserved Domains (3) summary
      pfam07798
      Location:538 → 659
      DUF1640; Protein of unknown function (DUF1640)
      pfam15905
      Location:368 → 711
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      cl07863
      Location:397 → 466
      Phasin; Poly(hydroxyalcanoate) granule associated protein (phasin)

    2. NM_001300418.1 → NP_001287347.1  uncharacterized protein Dmel_CG45105, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHA1
      Conserved Domains (3) summary
      pfam07798
      Location:538 → 659
      DUF1640; Protein of unknown function (DUF1640)
      pfam15964
      Location:191 → 685
      CCCAP; Centrosomal colon cancer autoantigen protein family
      cl07863
      Location:397 → 466
      Phasin; Poly(hydroxyalcanoate) granule associated protein (phasin)

    3. NM_001300419.1 → NP_001287348.1  uncharacterized protein Dmel_CG45105, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LIA2
      Conserved Domains (4) summary
      pfam07798
      Location:452 → 557
      DUF1640; Protein of unknown function (DUF1640)
      pfam15964
      Location:105 → 531
      CCCAP; Centrosomal colon cancer autoantigen protein family
      cl07863
      Location:311 → 380
      Phasin; Poly(hydroxyalcanoate) granule associated protein (phasin)
      cl24005
      Location:407 → 502
      DUF2570; Protein of unknown function (DUF2570)

    4. NM_001300416.1 → NP_001287345.1  uncharacterized protein Dmel_CG45105, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH69
      Conserved Domains (4) summary
      pfam07798
      Location:452 → 557
      DUF1640; Protein of unknown function (DUF1640)
      pfam15964
      Location:105 → 531
      CCCAP; Centrosomal colon cancer autoantigen protein family
      cl07863
      Location:311 → 380
      Phasin; Poly(hydroxyalcanoate) granule associated protein (phasin)
      cl24005
      Location:407 → 502
      DUF2570; Protein of unknown function (DUF2570)

    5. NM_001300415.1 → NP_001287344.1  uncharacterized protein Dmel_CG45105, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287344.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH69
      Conserved Domains (4) summary
      pfam07798
      Location:452 → 557
      DUF1640; Protein of unknown function (DUF1640)
      pfam15964
      Location:105 → 531
      CCCAP; Centrosomal colon cancer autoantigen protein family
      cl07863
      Location:311 → 380
      Phasin; Poly(hydroxyalcanoate) granule associated protein (phasin)
      cl24005
      Location:407 → 502
      DUF2570; Protein of unknown function (DUF2570)

    6. NM_169683.2 → NP_732086.1  uncharacterized protein Dmel_CG45105, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF12
      Related
      FBpp0311011
      Conserved Domains (3) summary
      pfam07798
      Location:452 → 573
      DUF1640; Protein of unknown function (DUF1640)
      pfam15905
      Location:282 → 625
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      cl07863
      Location:311 → 380
      Phasin; Poly(hydroxyalcanoate) granule associated protein (phasin)

    7. NM_001104338.2 → NP_001097808.1  uncharacterized protein Dmel_CG45105, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR11
      Conserved Domains (3) summary
      COG1340
      Location:302 → 581
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam07798
      Location:452 → 573
      DUF1640; Protein of unknown function (DUF1640)
      cl07863
      Location:311 → 380
      Phasin; Poly(hydroxyalcanoate) granule associated protein (phasin)

    8. NM_001300417.1 → NP_001287346.1  uncharacterized protein Dmel_CG45105, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287346.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHH2
      Conserved Domains (3) summary
      pfam07798
      Location:452 → 573
      DUF1640; Protein of unknown function (DUF1640)
      pfam15905
      Location:282 → 617
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      cl07863
      Location:311 → 380
      Phasin; Poly(hydroxyalcanoate) granule associated protein (phasin)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH69 A0A0B4LH69
    A0A0B4LHA1 A0A0B4LHA1
    A0A0B4LHH2 A0A0B4LHH2
    A0A0B4LIA2 A0A0B4LIA2
    Q6NR11 Q6NR11
    Q9VF12 Q9VF12
    Q9VF13 Q9VF13

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