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    Der-2 Derlin-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Der-2provided by FlyBase
    Official Full Name
    Derlin-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038438
    Locus tag
    Dmel_CG14899
    See related
    AllianceGenome:FB:FBgn0038438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cg14899; CG14899; dDer-2; DER1; Dmel\CG14899
    Summary
    Predicted to enable signal recognition particle binding activity. Involved in defense response to bacterium. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to several human genes including DERL2 (derlin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Der-2 in Genome Data Viewer
    Location:
    89B18-89B18; 3-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16482694..16484223, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12308416..12309945, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46029 Neighboring gene Guanylyl cyclase at 89Db Neighboring gene Succinate dehydrogenase assembly factor 3 Neighboring gene Dihydrofolate reductase Neighboring gene Cadherin 89D Neighboring gene Gustatory receptor 89a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Kang MJ, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805114, Free PMC Article
    2. Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis. Liang CJ, et al. PLoS Genet, 2014 Sep. PMID 25255315, Free PMC Article
    3. Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress. Fattouh N, et al. PLoS Negl Trop Dis, 2019 Mar. PMID 30893296, Free PMC Article
    4. Fast sequence evolution of Hox and Hox-derived genes in the genus Drosophila. Casillas S, et al. BMC Evol Biol, 2006 Dec 12. PMID 17163987, Free PMC Article
    5. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Ayres JS, et al. Genetics, 2008 Mar. PMID 18245331, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Derlin-2
    Names
    CG14899-PA
    Der-2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16482694..16484223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142296.3 → NP_650553.1  Derlin-2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650553.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEU2
      Related
      FBpp0082758
      Conserved Domains (1) summary
      pfam04511
      Location:11 → 201
      DER1; Der1-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEU2 Q9VEU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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