osa osa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: osaprovided by FlyBase
Official Full Name: osaprovided by FlyBase
Primary source: FLYBASE:FBgn0261885
Locus tag: Dmel_CG7467
See related: AllianceGenome:FB:FBgn0261885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.314; anon-WO0172774.126; ARID1B; C819; CG7467; Dmel\CG7467; E(E2F)3C; eld; en(lz)4F/4H; eyelid; l(3)00090; l(3)04539; l(3)j9C3; Osa; OSA; p300
Summary: Enables DNA binding activity. Involved in several processes, including generation of neurons; imaginal disc-derived appendage morphogenesis; and regulation of DNA-templated transcription. Located in nucleus and polytene chromosome. Part of brahma complex. Is expressed in several structures, including adult brain cell body rind; embryonic/larval fat body; embryonic/larval salivary gland; eye disc morphogenetic furrow; and imaginal disc. Used to study Coffin-Siris syndrome 1 and Coffin-Siris syndrome 2. Human ortholog(s) of this gene implicated in several diseases, including Coffin-Siris syndrome (multiple); breast cancer; carcinoma (multiple); gastrointestinal system cancer (multiple); and neuroblastoma. Orthologous to human ARID1A (AT-rich interaction domain 1A) and ARID1B (AT-rich interaction domain 1B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 90C1-90C2; 3-61 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17687818..17718350, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (13513540..13544072, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation.
Title: The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation.
Osa-Containing Brahma Complex Regulates Innate Immunity and the Expression of Metabolic Genes in Drosophila.
Title: Osa-Containing Brahma Complex Regulates Innate Immunity and the Expression of Metabolic Genes in Drosophila.
The authors propose that Osa and its target genes opa and D form an incoherent feedforward loop (FFL) and a new mechanism allowing the successive expression of temporal identities in intermediate neural progenitors.
Title: The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop.
Akirin orchestrates NF-kappaB transcriptional selectivity through the recruitment of the Osa-containing-SWI/SNF-like Brahma complex (BAP).
Title: Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling.
Study shows that Osa induces a transcriptional program in the transit-amplifying population that initiates temporal patterning, limits self-renewal, and prevents dedifferentiation and identifies the Prdm protein Hamlet as a key component of this program.
Title: SWI/SNF complex prevents lineage reversion and induces temporal patterning in neural stem cells.
TnaA physically interacts with the SUMO E2 conjugating enzyme Ubc9, and with the BRM complex subunit Osa.
Title: TnaA, an SP-RING protein, interacts with Osa, a subunit of the chromatin remodeling complex BRAHMA and with the SUMOylation pathway in Drosophila melanogaster.
Osa regulates intestinal stem cell self-renewal and differentiation into enterocytes by elaborating Notch signaling.
Title: The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine.
The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs.
Title: The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs.
suggest that one role of Osa and Brm in the wing is to establish a chromatin environment in the regulatory regions of EGFR target genes
Title: Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing.
Osa, a member of the Brahma chromatin-remodeling complex, as a positive modulator of Apterous activity in the Drosophila wing
Title: Osa modulates the expression of Apterous target genes in the Drosophila wing.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0253 (e-PCR)
- UniSTS:80848

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
contributes_to nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuroblast fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of SWI/SNF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SWI/SNF complex	IEA Inferred from Electronic Annotation more info
part_of brahma complex	IDA Inferred from Direct Assay more info	PubMed
part_of brahma complex	IEA Inferred from Electronic Annotation more info
part_of nBAF complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: osa

Names: CG7467-PA; CG7467-PB; CG7467-PC; CG7467-PD; CG7467-PE; CG7467-PF; eye lid; eyelid; osa-PA; osa-PB; osa-PC; osa-PD; osa-PE; osa-PF

NP_001163639.1

unusual splice

NP_001262680.1

unusual splice

NP_001262681.1

unusual splice

NP_524392.2

unusual splice

NP_996228.1

unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

17687818..17718350 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275751.1 → NP_001262680.1 osa, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262680.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHB1, B6IDZ6

Conserved Domains (2) summary

smart00501
Location:1000 → 1091

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

pfam12031
Location:2030 → 2290

DUF3518; Domain of unknown function (DUF3518)
NM_001170168.2 → NP_001163639.1 osa, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163639.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61603, Q8IN94, Q9VEG7

UniProtKB/TrEMBL

E1JIN6

Conserved Domains (2) summary

smart00501
Location:1001 → 1092

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

pfam12031
Location:2191 → 2451

DUF3518; Domain of unknown function (DUF3518)
NM_169775.2 → NP_732263.1 osa, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732263.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IN94

Related

FBpp0088544

Conserved Domains (2) summary

smart00501
Location:1001 → 1092

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

pfam12031
Location:2178 → 2438

DUF3518; Domain of unknown function (DUF3518)
NM_206506.2 → NP_996228.1 osa, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996228.1

Status: REVIEWED

UniProtKB/TrEMBL

B6IDZ6, Q7KSE8

Conserved Domains (2) summary

smart00501
Location:1001 → 1092

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

pfam12031
Location:2031 → 2291

DUF3518; Domain of unknown function (DUF3518)
NM_079668.3 → NP_524392.2 osa, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524392.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O61603, Q8IN94, Q9VEG7

UniProtKB/TrEMBL

E1JIN6

Related

FBpp0088543

Conserved Domains (2) summary

smart00501
Location:1001 → 1092

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

pfam12031
Location:2191 → 2451

DUF3518; Domain of unknown function (DUF3518)
NM_001275752.1 → NP_001262681.1 osa, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262681.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGD1, B6IDZ6

Conserved Domains (2) summary

smart00501
Location:1001 → 1095

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

pfam12031
Location:2034 → 2294

DUF3518; Domain of unknown function (DUF3518)