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    LTBP1 latent transforming growth factor beta binding protein 1 [ Gallus gallus (chicken) ]

    Gene ID: 421461, updated on 3-Dec-2024

    Summary

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    Symbol
    LTBP1provided by CGNC
    Full Name
    latent transforming growth factor beta binding protein 1provided by CGNC
    Primary source
    CGNC:51489
    See related
    Ensembl:ENSGALG00010007719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See LTBP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (30814381..30996860, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (30742332..30924844, complement)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417805 Neighboring gene uncharacterized LOC107052897 Neighboring gene family with sequence similarity 98 member A Neighboring gene RAS guanyl releasing protein 3 Neighboring gene uncharacterized LOC121110321 Neighboring gene uncharacterized LOC107052896 Neighboring gene uncharacterized LOC112532173 Neighboring gene tetratricopeptide repeat domain 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway. Chi JQ, et al. Virology, 2015 Feb. PMID 25528440
    2. Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos. Lorda-Diez CI, et al. BMC Dev Biol, 2010 Jun 21. PMID 20565961, Free PMC Article
    3. Non-coding RNAs revealed during identification of genes involved in chicken immune responses. Ahanda ML, et al. Immunogenetics, 2009 Jan. PMID 19009289
    4. Analysis of chicken embryonic gonad expressed sequenced tags. Shin JH, et al. Anim Genet, 2006 Feb. PMID 16441308
    5. Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index. Carre W, et al. Physiol Genomics, 2006 May 16. PMID 16554550

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Marek's disease virus microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-beta signaling pathway.
      Title: Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway.
    2. Latent Tgfbeta Binding protein 1 (LTBP1), which is a key extracellular modulator of Tgfbeta ligand bioavailability, is coexpressed with Tgfbetas in the chicken early limb bud.
      Title: Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    latent-transforming growth factor beta-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398250.1 → NP_001385179.1  latent-transforming growth factor beta-binding protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000063
      UniProtKB/TrEMBL
      A0A8V0XPE8
      Related
      ENSGALP00010010062.1, ENSGALT00010018374.1
      Conserved Domains (3) summary
      smart00179
      Location:1140 → 1181
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:977 → 1010
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      TIGR02813
      Location:709 → 827
      omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      30814381..30996860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015283725.4 → XP_015139211.2  latent-transforming growth factor beta-binding protein 1 isoform X6

      Conserved Domains (2) summary
      smart00179
      Location:1061 → 1102
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:898 → 931
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    2. XM_015283724.4 → XP_015139210.2  latent-transforming growth factor beta-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0XVP9
      Related
      ENSGALP00010010064.1, ENSGALT00010018377.1
      Conserved Domains (2) summary
      smart00179
      Location:1062 → 1103
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:899 → 932
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    3. XM_015283723.4 → XP_015139209.2  latent-transforming growth factor beta-binding protein 1 isoform X4

      Conserved Domains (2) summary
      smart00179
      Location:1085 → 1126
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:922 → 955
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    4. XM_015283721.4 → XP_015139207.2  latent-transforming growth factor beta-binding protein 1 isoform X1

      Conserved Domains (3) summary
      smart00179
      Location:1139 → 1180
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:976 → 1009
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      TIGR02813
      Location:709 → 826
      omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA

    5. XM_025148694.3 → XP_025004462.2  latent-transforming growth factor beta-binding protein 1 isoform X2

      Conserved Domains (3) summary
      smart00179
      Location:1099 → 1140
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:977 → 1010
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      TIGR02813
      Location:709 → 827
      omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA

    6. XM_015283722.4 → XP_015139208.2  latent-transforming growth factor beta-binding protein 1 isoform X3

      Conserved Domains (3) summary
      smart00179
      Location:1140 → 1181
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:977 → 1010
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      TIGR02813
      Location:709 → 827
      omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA

    7. XM_046938825.1 → XP_046794781.1  latent-transforming growth factor beta-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8V0XTQ7

    8. XM_046938824.1 → XP_046794780.1  latent-transforming growth factor beta-binding protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8V0XTQ7

    9. XM_040697088.2 → XP_040553022.1  latent-transforming growth factor beta-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V0XTQ7
      Related
      ENSGALP00010010061.1, ENSGALT00010018365.1
      Conserved Domains (2) summary
      smart00179
      Location:782 → 823
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:619 → 652
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    10. XM_046938823.1 → XP_046794779.1  latent-transforming growth factor beta-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8V0XTQ7

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      30742332..30924844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046913844.1 → XP_046769800.1  latent-transforming growth factor beta-binding protein 1 isoform X6

    2. XM_046913843.1 → XP_046769799.1  latent-transforming growth factor beta-binding protein 1 isoform X5

    3. XM_046913842.1 → XP_046769798.1  latent-transforming growth factor beta-binding protein 1 isoform X4

    4. XM_046913839.1 → XP_046769795.1  latent-transforming growth factor beta-binding protein 1 isoform X1

    5. XM_046913840.1 → XP_046769796.1  latent-transforming growth factor beta-binding protein 1 isoform X2

    6. XM_046913841.1 → XP_046769797.1  latent-transforming growth factor beta-binding protein 1 isoform X3

    7. XM_046913848.1 → XP_046769804.1  latent-transforming growth factor beta-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8V0XTQ7

    8. XM_046913847.1 → XP_046769803.1  latent-transforming growth factor beta-binding protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8V0XTQ7

    9. XM_046913846.1 → XP_046769802.1  latent-transforming growth factor beta-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V0XTQ7

    10. XM_046913849.1 → XP_046769805.1  latent-transforming growth factor beta-binding protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8V0XTQ7

    11. XM_046913845.1 → XP_046769801.1  latent-transforming growth factor beta-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8V0XTQ7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001282608.2: Suppressed sequence

      Description
      NM_001282608.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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