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    ITGB1BP1 integrin subunit beta 1 binding protein 1 [ Gallus gallus (chicken) ]

    Gene ID: 421928, updated on 3-Dec-2024

    Summary

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    Symbol
    ITGB1BP1provided by CGNC
    Full Name
    integrin subunit beta 1 binding protein 1provided by CGNC
    Primary source
    CGNC:12293
    See related
    Ensembl:ENSGALG00010003253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ITGB1BP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (95874596..95881784, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (95690490..95697668, complement)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene kinase D-interacting substrate 220kDa Neighboring gene membrane bound O-acyltransferase domain containing 2 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of chicken embryonic gonad expressed sequenced tags. Shin JH, et al. Anim Genet, 2006 Feb. PMID 16441308
    2. Expressed sequence tag analysis of Eimeria-stimulated intestinal intraepithelial lymphocytes in chickens. Min W, et al. Mol Biotechnol, 2005 Jun. PMID 15920284
    3. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin beta-1-binding protein 1
    Names
    integrin beta 1 binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278034.1 → NP_001264963.1  integrin beta-1-binding protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BU144417, BU341177, BU458846, BX950700, CV854210
      UniProtKB/TrEMBL
      A0A8V0XD08
      Conserved Domains (1) summary
      cl17171
      Location:1 → 207
      PH-like; Pleckstrin homology-like domain

    2. NM_001278035.1 → NP_001264964.1  integrin beta-1-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001264964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BU144417, BU341177, BX950700, CV854210
      UniProtKB/TrEMBL
      A0A8V0XD08, A0A8V0XJW8
      Conserved Domains (1) summary
      cl17171
      Location:1 → 199
      PH-like; Pleckstrin homology-like domain

    3. NM_001278036.1 → NP_001264965.1  integrin beta-1-binding protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BU144417, BU341177, BX950700, CD738050, CV854210
      UniProtKB/TrEMBL
      A0A1D5PVN4, A0A8V0XD08
      Related
      ENSGALP00010004552.1, ENSGALT00010007621.1
      Conserved Domains (1) summary
      cl17171
      Location:1 → 168
      PH-like; Pleckstrin homology-like domain

    4. NM_001278038.1 → NP_001264967.1  integrin beta-1-binding protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001264967.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an additional exon in the 5' region and an alternate splice site in the central region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform 4.
      Source sequence(s)
      BU144417, BU341177, BX950700, CV854210
      UniProtKB/TrEMBL
      A0A1D5PR50
      Conserved Domains (1) summary
      cl17171
      Location:1 → 88
      PH-like; Pleckstrin homology-like domain

    5. NM_001278052.1 → NP_001264981.1  integrin beta-1-binding protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001264981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate splice site in the central region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform 4.
      Source sequence(s)
      BU144417, BU341177, BU367456, BX936058, BX950700
      UniProtKB/TrEMBL
      A0A1D5PR50
      Conserved Domains (1) summary
      cl17171
      Location:1 → 88
      PH-like; Pleckstrin homology-like domain

    RNA

    1. NR_102745.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has an additional exon in the 5' region and an alternate splice site in the central region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BU144417, BU341177, BU367456, BX950700

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      95874596..95881784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040697190.2 → XP_040553124.1  integrin beta-1-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XD13
      Related
      ENSGALP00010004561.1, ENSGALT00010007630.1
      Conserved Domains (1) summary
      cl17171
      Location:1 → 149
      PH-like; Pleckstrin homology-like domain

    2. XM_015276036.4 → XP_015131522.1  integrin beta-1-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XD08, A0A8V0XJW8
      Related
      ENSGALP00010004563.1, ENSGALT00010007632.1
      Conserved Domains (1) summary
      cl17171
      Location:1 → 199
      PH-like; Pleckstrin homology-like domain

    3. XM_025148774.3 → XP_025004542.1  integrin beta-1-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XD08
      Conserved Domains (1) summary
      cl17171
      Location:1 → 207
      PH-like; Pleckstrin homology-like domain

    4. XM_046938926.1 → XP_046794882.1  integrin beta-1-binding protein 1 isoform X4

    5. XM_046938927.1 → XP_046794883.1  integrin beta-1-binding protein 1 isoform X4

    6. XM_046938925.1 → XP_046794881.1  integrin beta-1-binding protein 1 isoform X4

    7. XM_046938924.1 → XP_046794880.1  integrin beta-1-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XD08, A0A8V0XJW8

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      95690490..95697668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046914154.1 → XP_046770110.1  integrin beta-1-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A1D5PVN4, A0A8V0XD08

    2. XM_046914155.1 → XP_046770111.1  integrin beta-1-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XD13

    3. XM_046914152.1 → XP_046770108.1  integrin beta-1-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XD08, A0A8V0XJW8

    4. XM_046914151.1 → XP_046770107.1  integrin beta-1-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XD08

    5. XM_046914157.1 → XP_046770113.1  integrin beta-1-binding protein 1 isoform X4

    6. XM_046914158.1 → XP_046770114.1  integrin beta-1-binding protein 1 isoform X4

    7. XM_046914156.1 → XP_046770112.1  integrin beta-1-binding protein 1 isoform X4

    8. XM_046914153.1 → XP_046770109.1  integrin beta-1-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XD08, A0A8V0XJW8
    Nucleotide Protein Strain
    Heading Accession and Version

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