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    NP15.6 NP15.6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NP15.6provided by FlyBase
    Official Full Name
    NP15.6provided by FlyBase
    Primary source
    FLYBASE:FBgn0027785
    Locus tag
    Dmel_CG6008
    See related
    AllianceGenome:FB:FBgn0027785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.281; CG6008; Dmel\CG6008; dNDUFB11; ND-15.6; NDUFB11
    Summary
    Predicted to be involved in respiratory electron transport chain. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 3 and nuclear type mitochondrial complex I deficiency 30. Orthologous to human NDUFB11 (NADH:ubiquinone oxidoreductase subunit B11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NP15.6 in Genome Data Viewer
    Location:
    91E4-91E4; 3-65 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19027368..19028015)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14853090..14853737)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamyl-tRNA amidotransferase, subunit A Neighboring gene Pyrroline 5-carboyxlate reductase Neighboring gene Prp18 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extraordinarily high density of unrelated genes showing overlapping and intraintronic transcription units. Misener SR, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 10858562
    2. Mutations in the Drosophila mitochondrial tRNA amidotransferase, bene/gatA, cause growth defects in mitotic and endoreplicating tissues. Morris JZ, et al. Genetics, 2008 Feb. PMID 18245325, Free PMC Article
    3. The mitochondrial ribosomal protein mRpL4 regulates Notch signaling. Mo D, et al. EMBO Rep, 2023 Jun 5. PMID 37009823, Free PMC Article
    4. Senescent glia link mitochondrial dysfunction and lipid accumulation. Byrns CN, et al. Nature, 2024 Jun. PMID 38839958, Free PMC Article
    5. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in respiratory electron transport chain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NP15.6
    Names
    CG6008-PA
    NP15.6-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19027368..19028015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142517.3 → NP_650774.1  NP15.6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650774.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3L7
      Related
      FBpp0083126
      Conserved Domains (1) summary
      pfam10183
      Location:36 → 121
      ESSS; ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3L7 Q9V3L7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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