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    sba six-banded [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42824, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sbaprovided by FlyBase
    Official Full Name
    six-bandedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016754
    Locus tag
    Dmel_CG13598
    See related
    AllianceGenome:FB:FBgn0016754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF56201; CG13598; Dm Sba; dMBD5/6; Dmel\CG13598; DMTF125; F125; MBD5; SBA; Tf125; TF125
    Summary
    Predicted to enable chromatin binding activity. Predicted to be active in chromocenter and nucleus. Human ortholog(s) of this gene implicated in autism spectrum disorder and autosomal dominant intellectual developmental disorder 1. Orthologous to several human genes including MBD5 (methyl-CpG binding domain protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sba in Genome Data Viewer
    Location:
    95C9-95C12; 3-81 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23894174..23922973, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19719896..19748695, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Transcription-factor-IIA-S Neighboring gene testis-specifically expressed bromodomain containing protein-1 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Nuclear division cycle 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. six-banded, a novel Drosophila gene, is expressed in 6 segmental stripes during embryonic development and in the eye imaginal disc. Zeidler MP, et al. Biol Chem, 1997 Oct. PMID 9372180
    2. Gene dosage and selective expression modify phenotype in a Drosophila model of human mitochondrial disease. Toivonen JM, et al. Mitochondrion, 2003 Oct. PMID 16120347
    3. Population genetic evidence for cold adaptation in European Drosophila melanogaster populations. Božičević V, et al. Mol Ecol, 2016 Mar. PMID 26558479
    4. Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability. Kleefstra T, et al. Am J Hum Genet, 2012 Jul 13. PMID 22726846, Free PMC Article
    5. Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation. Kennington WJ, et al. Genetics, 2006 Mar. PMID 16322502, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    six-banded
    Names
    CG13598-PC
    CG13598-PD
    CG13598-PE
    CG13598-PF
    CG13598-PG
    CG13598-PH
    CG13598-PI
    TF125 type II
    methyl-CpG-binding domain protein 5/6
    sba-PC
    sba-PD
    sba-PE
    sba-PF
    sba-PG
    sba-PH
    sba-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23894174..23922973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176549.3 → NP_788726.2  six-banded, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788726.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K7E4, A0A0B4KHQ9, A0A0B4KHZ2, A0A0C4DHB2, A8JR92, A8JR93, Q24552, Q94892
      UniProtKB/TrEMBL
      Q95TH4
      Conserved Domains (2) summary
      smart00391
      Location:241 → 315
      MBD; Methyl-CpG binding domain
      cl02554
      Location:1344 → 1440
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    2. NM_170094.4 → NP_732911.2  six-banded, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732911.2

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00391
      Location:241 → 315
      MBD; Methyl-CpG binding domain

    3. NM_001260342.2 → NP_001247271.1  six-banded, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TH4
      Conserved Domains (1) summary
      smart00391
      Location:241 → 315
      MBD; Methyl-CpG binding domain

    4. NM_001104423.2 → NP_001097893.1  six-banded, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097893.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K7E4, A0A0B4KHQ9, A0A0B4KHZ2, A0A0C4DHB2, A8JR92, A8JR93, Q24552, Q94892
      UniProtKB/TrEMBL
      Q95TH4
      Conserved Domains (2) summary
      smart00391
      Location:241 → 315
      MBD; Methyl-CpG binding domain
      cl02554
      Location:1344 → 1440
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    5. NM_001275959.1 → NP_001262888.1  six-banded, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TH4
      Conserved Domains (2) summary
      smart00391
      Location:241 → 315
      MBD; Methyl-CpG binding domain
      cl02554
      Location:1344 → 1440
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    6. NM_001275960.1 → NP_001262889.1  six-banded, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262889.1

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00391
      Location:241 → 315
      MBD; Methyl-CpG binding domain

    7. NM_001104422.3 → NP_001097892.1  six-banded, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097892.1

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00391
      Location:241 → 315
      MBD; Methyl-CpG binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7E4 A0A0B4K7E4
    A0A0B4KHQ9 A0A0B4KHQ9
    A0A0B4KHZ2 A0A0B4KHZ2
    A0A0C4DHB2 A0A0C4DHB2
    A8JR92 A8JR92
    A8JR93 A8JR93
    Q24552 Q24552
    Q94892 Q94892
    Q95TH4 Q95TH4

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