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    Polr2L RNA polymerase II, I and III subunit L [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42942, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr2Lprovided by FlyBase
    Official Full Name
    RNA polymerase II, I and III subunit Lprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039218
    Locus tag
    Dmel_CG13628
    See related
    AllianceGenome:FB:FBgn0039218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD08670; CG13628; Dmel\CG13628; Rpb10; RPB10
    Summary
    Predicted to enable zinc ion binding activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Orthologous to human POLR2L (RNA polymerase II, I and III subunit L). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr2L in Genome Data Viewer
    Location:
    96A18-96A18; 3-85 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24717511..24717998)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20543233..20543720)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene slowpoke Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tolkin Neighboring gene tolloid

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assessment of the roles of Spt5-nucleic acid contacts in promoter proximal pausing of RNA polymerase II. Dollinger R, et al. J Biol Chem, 2023 Sep. PMID 37517697, Free PMC Article
    2. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
    3. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Zdobnov EM, et al. Science, 2002 Oct 4. PMID 12364792
    4. Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation. Aoyagi N, et al. J Cell Biol, 2000 Jul 24. PMID 10908585, Free PMC Article
    5. Identification of genetic suppressors of the Sin3A knockdown wing phenotype. Swaminathan A, et al. PLoS One, 2012. PMID 23166712, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA-directed 5'-3' RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase I activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II, I and III subunit L
    Names
    CG13628-PA
    Polr2L-PA
    Rpb10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24717511..24717998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143023.2 → NP_651280.1  RNA polymerase II, I and III subunit L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651280.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VC49
      UniProtKB/TrEMBL
      A0A1B2AKT8
      Related
      FBpp0084067
      Conserved Domains (1) summary
      PLN00032
      Location:1 → 67
      PLN00032; DNA-directed RNA polymerase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC49.1 Q9VC49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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