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    Ctl2 Choline transporter-like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctl2provided by FlyBase
    Official Full Name
    Choline transporter-like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039637
    Locus tag
    Dmel_CG11880
    See related
    AllianceGenome:FB:FBgn0039637
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11880; CTLH2; DmCTL2; Dmel\CG11880
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and dorsal median cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 72. Orthologous to several human genes including SLC44A2 (solute carrier family 44 member 2 (CTL2 blood group)) and SLC44A5 (solute carrier family 44 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ctl2 in Genome Data Viewer
    Location:
    98F10-98F12; 3-97 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29123370..29128247)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24949092..24953969)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pyruvate dehydrogenase E1 beta subunit Neighboring gene Autophagy-related 14 Neighboring gene yemanuclein Neighboring gene dim gamma-tubulin 6 Neighboring gene Vacuolar H[+] ATPase 100kD subunit 1 Neighboring gene Alg13 UDP-N-acetylglucosaminyltransferase subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development. Duan Y, et al. Insect Biochem Mol Biol, 2022 Feb. PMID 34982980
    2. julius seizure, a Drosophila Mutant, Defines a Neuronal Population Underlying Epileptogenesis. Horne M, et al. Genetics, 2017 Mar. PMID 28082408, Free PMC Article
    3. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Traiffort E, et al. J Neurochem, 2005 Mar. PMID 15715662
    4. Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing. Garelli A, et al. Nat Commun, 2015 Oct 29. PMID 26510564, Free PMC Article
    5. Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. Zhang D, et al. Chromosoma, 2011 Feb. PMID 20857302

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development.
      Title: Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    choline transporter-like 2
    Names
    CG11880-PA
    CG11880-PB
    CG11880-PC
    Ctl2-PA
    Ctl2-PB
    Ctl2-PC
    choline transporter (CTL)-like protein 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29123370..29128247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143413.2 → NP_651670.1  choline transporter-like 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651670.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VAP3
      UniProtKB/TrEMBL
      C4XVJ5
      Related
      FBpp0084740
      Conserved Domains (1) summary
      pfam04515
      Location:407 → 761
      Choline_transpo; Plasma-membrane choline transporter

    2. NM_170389.2 → NP_733268.1  choline transporter-like 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VAP3
      UniProtKB/TrEMBL
      C4XVJ5
      Related
      FBpp0084741
      Conserved Domains (1) summary
      pfam04515
      Location:407 → 761
      Choline_transpo; Plasma-membrane choline transporter

    3. NM_170390.2 → NP_733269.1  choline transporter-like 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733269.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VAP3
      UniProtKB/TrEMBL
      C4XVJ5
      Related
      FBpp0084742
      Conserved Domains (1) summary
      pfam04515
      Location:407 → 761
      Choline_transpo; Plasma-membrane choline transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR01 Q8MR01
    Q9VAP3.1 Q9VAP3

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