alph alphabet [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: alphprovided by FlyBase
Official Full Name: alphabetprovided by FlyBase
Primary source: FLYBASE:FBgn0086361
Locus tag: Dmel_CG1906
See related: AllianceGenome:FB:FBgn0086361
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Alph; CG1906; Dmel\CG1906; pp2c99B; PP2Cb; SK3-1
Summary: Enables protein serine/threonine phosphatase activity. Involved in several processes, including determination of adult lifespan; imaginal disc fusion, thorax closure; and regulation of MAPK cascade. Predicted to be active in cytosol and nucleus. Is expressed in adult head. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A) and PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99B4-99B5; 3-99 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29591831..29617157)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25417553..25442879)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epistasis experiments suggest that Alph acts at a step upstream of the MAPKKs Hep and Lic.
Title: The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc fusion, thorax closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	HGI more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of R7 cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Ras protein signal transduction	HGI more info	PubMed
involved_in negative regulation of photoreceptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of stress-activated MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of stress-activated protein kinase signaling cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of stress-activated protein kinase signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of p38MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to UV-C	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to paraquat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alphabet

Names: CG1906-PA; CG1906-PB; CG1906-PC; CG1906-PD; CG1906-PE; CG1906-PF; alph-PA; alph-PB; alph-PC; alph-PD; alph-PE; alph-PF; pp2c99B

NP_001247356.1

EC 3.1.3.16

NP_651701.1

EC 3.1.3.16

NP_733295.1

EC 3.1.3.16

NP_733296.1

EC 3.1.3.16

NP_733297.1

EC 3.1.3.16

NP_733298.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

29591831..29617157

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143444.4 → NP_651701.1 alphabet, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651701.1

Status: REVIEWED

UniProtKB/TrEMBL

D6W4T6, Q961C5

Related

FBpp0084810

Conserved Domains (2) summary

cd00143
Location:24 → 284

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:278 → 352

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
NM_170419.3 → NP_733298.1 alphabet, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733298.1

Status: REVIEWED

UniProtKB/TrEMBL

D6W4T6, Q8IMK7

Related

FBpp0084809

Conserved Domains (2) summary

cd00143
Location:24 → 284

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:278 → 352

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
NM_170416.3 → NP_733295.1 alphabet, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733295.1

Status: REVIEWED

UniProtKB/TrEMBL

D6W4T6, Q9VAK1

Related

FBpp0084808

Conserved Domains (2) summary

cd00143
Location:24 → 284

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:278 → 352

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
NM_001260427.2 → NP_001247356.1 alphabet, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247356.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7Q3, D6W4T6

Conserved Domains (2) summary

cd00143
Location:24 → 284

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:278 → 311

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
NM_170418.3 → NP_733297.1 alphabet, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733297.1

Status: REVIEWED

UniProtKB/TrEMBL

D6W4T6, Q9VAK1

Related

FBpp0084811

Conserved Domains (2) summary

cd00143
Location:24 → 284

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:278 → 352

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
NM_170417.3 → NP_733296.1 alphabet, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733296.1

Status: REVIEWED

UniProtKB/TrEMBL

D6W4T6, Q9VAK1

Related

FBpp0084812

Conserved Domains (2) summary

cd00143
Location:24 → 284

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:278 → 352

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain