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    metl-2 tRNA N(3)-methylcytidine methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 4363033, updated on 4-Jan-2025

    Summary

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    Official Symbol
    metl-2
    Official Full Name
    tRNA N(3)-methylcytidine methyltransferase
    Primary source
    WormBase:WBGene00044720
    Locus tag
    CELE_Y53F4B.42
    See related
    AllianceGenome:WB:WBGene00044720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in RNA methylation. Orthologous to several human genes including METTL2A (methyltransferase 2A, tRNA N3-cytidine) and METTL2B (methyltransferase 2B, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See metl-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (14969900..14971657)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Elongation of very long chain fatty acids protein Neighboring gene Transcription factor CBF/NF-Y/archaeal histone domain-containing protein Neighboring gene 26S rRNA (cytosine-C(5))-methyltransferase nsun-5 Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine-3-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA N(3)-methylcytidine methyltransferase
    NP_001040827.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14969900..14971657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047362.5 → NP_001040827.1  tRNA N(3)-methylcytidine methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040827.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2MDF2
      Conserved Domains (3) summary
      COG0500
      Location:70 → 309
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:122 → 226
      Methyltransf_12; Methyltransferase domain
      cl17173
      Location:206 → 278
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version

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