tll tailless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tllprovided by FlyBase
Official Full Name: taillessprovided by FlyBase
Primary source: FLYBASE:FBgn0003720
Locus tag: Dmel_CG1378
See related: AllianceGenome:FB:FBgn0003720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1378; dm-tll; Dmel\CG1378; NR2E2; Tailless; Tll; TLL
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription corepressor binding activity. Involved in several processes, including inter-male aggressive behavior; nervous system development; and regulation of transcription by RNA polymerase II. Is expressed in several structures, including anlage in statu nascendi; head epidermis primordium; neuromere; procephalic neuroblast; and supraesophageal ganglion. Used to study brain cancer. Orthologous to human NR2E1 (nuclear receptor subfamily 2 group E member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 100A6-100A6; 3-101 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30852315..30854400)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26678037..26680122)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Global repression by tailless during segmentation.
Title: Global repression by tailless during segmentation.
Polycomb repressive complex 1 initiates and maintains tailless repression in Drosophila embryo.
Title: Polycomb repressive complex 1 initiates and maintains tailless repression in Drosophila embryo.
The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
Title: The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1.
Title: Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1.
the relationship between the transcription repressor Tailless and the transcription stimulation of genes coding for engulfment receptors in Drosophila hemocytes following stimulation with apoptotic cells
Title: Transcription repressor-mediated control of engulfment receptor expression in Drosophila phagocytes.
TLL is a newly-identified component of a combinatorial network of repressor genes that control pair-rule stripe formation in the anterior blastoderm of Drosophila.
Title: Repression activity of Tailless on h 1 and eve 1 pair-rule stripes.
We then show that Rx controls proliferation within the MBNB clones independently of Tailless (Tll) and Prospero (Pros), and does not regulate the expression of other key regulators of MB development, Eyeless (Ey) and Dachshund (Dac). Our data support that the role of Rx in forebrain development is conserved between vertebrates and fly.
Title: Retinal homeobox promotes cell growth, proliferation and survival of mushroom body neuroblasts in the Drosophila brain.
Knockdown of Atrophin, a Tll co-repressor, also increases aggression, and both proteins physically interact in the PI. tll knockdown-induced aggression is fully suppressed by blocking neuropeptide processing or release from the PI
Title: Tailless and Atrophin control Drosophila aggression by regulating neuropeptide signalling in the pars intercerebralis.
tll regulates the precise timing of the transition from neuroepithelial cells to medulla neuroblasts; tll has a crucial role for the specification of lamina precursor cells
Title: Characterization of tailless functions during Drosophila optic lobe formation.
Both position and timing of posterior segmentation gene expression domains vary strongly from embryo-to-embryo in tll mutants.
Title: Lack of tailless leads to an increase in expression variability in Drosophila embryos.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Bolwig's organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	TAS Traceable Author Statement more info	PubMed
involved_in insect visual primordium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inter-male aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ring gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal release	IGI Inferred from Genetic Interaction more info	PubMed
involved_in terminal region determination	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tailless

Names: CG1378-PA; tailles; tll-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

30852315..30854400

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079857.4 → NP_524596.1 tailless [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524596.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P18102, Q4V6W1, Q9VA33

Related

FBpp0085071

Conserved Domains (2) summary

cd07163
Location:25 → 117

NR_DBD_TLX; DNA-binding domain of Tailless (TLX) is composed of two C4-type zinc fingers

cl11397
Location:215 → 436

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators